ArticlePharmaceutical biology2018
Anti-neuroinflammatory effects of cudraflavanone A isolated from the chloroform fraction of Cudrania tricuspidata root bark.
Article in Pharmaceutical biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Optimization of Extraction Process by Response Surface Methodology, Composition Analysis and Antioxidant Activity of Total Flavonoids fromMolecules (Basel, Switzerland) · 2026Article
- Serum trihalomethanes and cognitive decline: investigating environmental risk factors for neurodegenerative diseases.Frontiers in public health · 2025Article
- NO classifier prediction of anti neuroinflammatory agents using text mining of 3D molecular fingerprints.Scientific reports · 2024Article
- Prenylated Flavonoids of the Moraceae Family: A Comprehensive Review of Their Biological Activities.Plants (Basel, Switzerland) · 2024Review
- The ethanolic extract of Curcuma longa grown in Korea exhibits anti-neuroinflammatory effects by activating of nuclear transcription factor erythroid-2-related factor 2/heme oxygenase-1 signaling pathway.BMC complementary medicine and therapies · 2022Article
- Nitric Oxide as a Target for Phytochemicals in Anti-Neuroinflammatory Prevention Therapy.International journal of molecular sciences · 2021Review
- Protective Effect ofMolecules (Basel, Switzerland) · 2021Article
- Enhanced Nrf2 up-regulation by extracellular basic pH in a human skin equivalent system.Journal of cellular and molecular medicine · 2021Article
- Article
- Chemical Analysis of the Ingredients of 20% Aqueous Ethanol Extract ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Cudrania tricuspidata Root Extract Prevents Methylglyoxal-Induced Inflammation and Oxidative Stress via Regulation of the PKC-NOX4 Pathway in Human Kidney Cells.Oxidative medicine and cellular longevity · 2021Article
- Anti-Inflammatory and Cytotoxicity Effects ofFoods (Basel, Switzerland) · 2020Article
- Neuroprotective and Anti-Inflammatory Effects of Kuwanon C fromInternational journal of molecular sciences · 2020Article
- Chemical Constituents and an Antineuroinflammatory Lignan, Savinin from the Roots ofEvidence-based complementary and alternative medicine : eCAM · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextCudrania tricuspidata Bureau (Moraceae) is an important source of traditional Korean and Chinese medicines used to treat neuritis and inflammation.
objectiveThe anti-neuroinflammatory effects of cudraflavanone A isolated from a chloroform fraction of C. tricuspidata were investigated in LPS-induced BV2 cells. MATERIALS AND
methodsCudraflavanone A was isolated from the root of C. tricuspidata, and its structure was determined by MS and NMR data. Cytotoxicity of the compound was examined by MTT assay, indicating no cytotoxicity at 5-40 μM of cudraflavanone A. NO concentration was measured by the Griess reaction, and the levels of PGE
resultsCudraflavanone A had no major effect on cell viability at 40 μM indicating 91.5% viability. It reduced the production of NO (IC DISCUSSION AND
conclusionsThe present study suggests a potent effect of cudraflavanone A to prevent neuroinflammatory diseases. Further investigation is necessary to elucidate specific molecular mechanism of cudraflavanone A.
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