Evidence map›Paper›PMID 29521005›Full record

ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2018

PGC1β Organizes the Osteoclast Cytoskeleton by Mitochondrial Biogenesis and Activation.

Yan Zhang, Nidhi Rohatgi, Deborah J Veis, Joel Schilling, Steven L Teitelbaum, Wei Zou

Open access · bronzeAbstract read
In one paragraph

Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 65 citations in OpenAlex.

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  20. Bone metabolism - an underappreciated player.npj metabolic health and disease · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 3 countries.

Yan ZhangDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Nidhi RohatgiDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Deborah J VeisDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Joel SchillingDepartment of Medicine, Division of Cardiology, Washington University School of Medicine, St. Louis, MO, USA.
Steven L TeitelbaumDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Wei ZouDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Washington University in St. Louis · USSaint Louis University · ES

Funding

Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Brian N Finck · 1999 to 2026
$30.2M
WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Jennifer Lynn Powers Carson · 2013 to 2026
$27.1M
The Role of the Osteoblast Secretome in Bone FormationP30AR057235 · NIAMS · WASHINGTON UNIVERSITY · PI SILVA, MATTHEW J · 2009 to 2018
$5.7M
Mechanisms of AVB3 Integrin Mediated Bone ResorptionR37AR046523 · NIAMS · WASHINGTON UNIVERSITY · PI TEITELBAUM, STEVEN L · 2010 to 2019
$3.3M
FAT TALKS TO BONER01DK111389 · NIDDK · WASHINGTON UNIVERSITY · PI TEITELBAUM, STEVEN L · 2017 to 2021
$1.9M
Role of Mitochondrial Dynamics In Bone HomeostasisR01AR070030 · NIAMS · WASHINGTON UNIVERSITY · PI VEIS, DEBORAH J · 2016 to 2020
$1.8M
MACROPHAGE METABOLISM AND INFLAMMATION IN METABOLIC DISEASER01DK110034 · NIDDK · WASHINGTON UNIVERSITY · PI SCHILLING, JOEL DAVID · 2016 to 2020
$1.7M
NIAMS NIH HHS P30 AR057235NIAMS NIH HHS R01 AR070030NIAMS NIH HHS R37 AR046523NIDDK NIH HHS P30 DK020579NIDDK NIH HHS P30 DK056341NIDDK NIH HHS R01 DK110034NIDDK NIH HHS R01 DK111389
6 · The paper itself

Abstract

Osteoclasts are mitochondria-rich cells, but the role of these energy-producing organelles in bone resorption is poorly defined. To this end, we conditionally deleted the mitochondria-inducing co-activator, PGC1β, in myeloid lineage cells to generate PGC1β

Indexed as

Organelle BiogenesisAnimalsCell Cycle ProteinsCell DifferentiationCytoskeletonFemurGTPase-Activating ProteinsMice, TransgenicMitochondriaOrgan SizeOsteoclastsOxidative PhosphorylationPaxillinPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaCell Cycle ProteinsGit1 protein, mouseGTPase-Activating ProteinsPaxillinPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPpargc1a protein, mouseCYTOSKELETONMITOCHONDRIAL BIOGENESISOSTEOCLASTSPGC1β

Identifiers

PMID29521005
PMCPMC6002881
OpenAlexW2789608730

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.