Evidence map›Paper›PMID 29520950›Full record

ArticleJournal of periodontology2018

Early intervention of peri-implantitis and periodontitis using a mouse model.

Ryan L Wong, Sarah Hiyari, Aline Yaghsezian, Mina Davar, Maísa Casarin, Yi-Ling Lin, Sotirios Tetradis, Paulo M Camargo, Flavia Q Pirih

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of periodontology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 36 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Ryan L WongUniversity of California, Los Angeles, Section of Periodontics, Los Angeles, California.
Sarah HiyariUniversity of California, Los Angeles, Section of Periodontics, Los Angeles, California.
Aline YaghsezianUniversity of California, Los Angeles, Section of Periodontics, Los Angeles, California.
Mina DavarUniversity of California, Los Angeles, Section of Periodontics, Los Angeles, California.
Maísa CasarinFederal University of Santa Maria, Department of Stomatology, Santa Maria, Rio Grande do Sul, Brazil.
Yi-Ling LinUniversity of California, Los Angeles, Section of Oral and Maxillofacial Pathology, Los Angeles, California.
Sotirios TetradisUniversity of California, Los Angeles, Section of Oral and Maxillofacial Radiology, Los Angeles, California.
Paulo M CamargoUniversity of California, Los Angeles, Section of Periodontics, Los Angeles, California.
Flavia Q PirihUniversity of California, Los Angeles, Section of Periodontics, Los Angeles, California.
University of California, Los Angeles · USUniversidade Federal de Santa Maria · BR

Funding

UCLA Clinical and Translational Science InstituteTL1TR000121 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$2.7M
UCLA Dentist-Scientist and Oral Health-Researcher Training ProgramT90DE022734 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WONG, DAVID T · 2012 to 2017
$2.3M
NCATS NIH HHS TL1 TR000121NIDCR NIH HHS T90 DE022734
6 · The paper itself

Abstract

backgroundPeri-implantitis is an inflammatory response to bacterial biofilm resulting in bone loss and can ultimately lead to implant failure. Because of the lack of predictable treatments available, a thorough understanding of peri-implantitis's pathogenesis is essential. The objective of this study is to evaluate and compare the response of acute induced peri-implantitis and periodontitis lesions after insult removal.

methodsImplants were placed in one-month-old C57BL/6J male mice eight weeks post extraction of their left maxillary molars. Once osseointegrated, ligatures were placed around the implants and contralateral second molars of the experimental groups. Controls did not receive ligatures. After one week, half of the ligatures were removed, creating the ligature-retained and ligature-removed groups. Mice were sacrificed at two time points, 5 and 14 days, from ligature removal. The specimens were analyzed via micro-computed tomography and histology.

resultsBy 5 and 14 days after ligature removal, the periodontitis group experienced significant bone gain, whereas the peri-implantitis group did not. Histologically, all implant groups exhibited higher levels of cellular infiltrate than any of the tooth groups. Osteoclast numbers increased in peri-implantitis and periodontitis ligature-retained groups and decreased following insult removal. Collagen was overall more disorganized in peri-implantitis than periodontitis for all groups. Peri-implantitis experimental groups revealed greater matrix metalloproteinase-8 and NF-kB levels than periodontitis.

conclusionsImplants respond slower and less favorably to insult removal than teeth. Future research is needed to characterize detailed peri-implantitis disease pathophysiology.

Indexed as

Dental ImplantsPeri-ImplantitisPeriodontitisAnimalsLigationMaleMiceMice, Inbred C57BLX-Ray MicrotomographyDental Implantsdental implantligaturemiceperi-implantitisperiodontitis

Identifiers

PMID29520950
PMCPMC8607848
OpenAlexW2791427294

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.