ArticleEuropean journal of pain (London, England)2018
Delineation between different components of chronic pain using dimension reduction - an ASL fMRI study in hand osteoarthritis.
Article in European journal of pain (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Preliminary report: parasympathetic tone links to functional brain networks during the anticipation and experience of visceral pain.Scientific reports · 2018Trial
- Reduced anterior cingulate grey matter volume in painful hand osteoarthritis.Rheumatology international · 2018Trial
- Assessing the Modulatory Effects of tDCS and Acupuncture on Cerebral Blood Flow in Chronic Low Back Pain Using Arterial Spin Labeling Perfusion Imaging.Brain sciences · 2025Article
- Pain modulatory network is influenced by sex and age in a healthy state and during osteoarthritis progression in rats.Aging cell · 2021Article
- Neural plasticity secondary to carpal tunnel syndrome: a pseudo-continuous arterial spin labeling study.Neural regeneration research · 2021Article
- CORR Insights®: Patients With Thumb-base Osteoarthritis Scheduled for Surgery Have More Symptoms, Worse Psychological Profile, and Higher Expectations Than Nonsurgical Counterparts: A Large Cohort Analysis.Clinical orthopaedics and related research · 2019Article
- Imaging Clinically Relevant Pain States Using Arterial Spin Labeling.Pain reports · 2019Article
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Authors and funding
8 authors at 2 institutions in 4 countries.
Funding
Abstract
backgroundTraditional psychometric measures aimed at characterizing the pain experience often show considerable overlap, due to interlinked affective and modulatory processes under central nervous system control. Neuroimaging studies have been employed to investigate this complexity of pain processing, in an attempt to provide a quantifiable, adjunctive description of pain perception. In this exploratory study, we examine psychometric and neuroimaging data from 38 patients with painful osteoarthritis of the carpometacarpal joint. We had two aims: first, to utilize principal component analysis (PCA) as a dimension reduction strategy across multiple self-reported endpoints of pain, cognitive and affective functioning; second, to investigate the relationship between identified dimensions and regional cerebral blood flow (rCBF) as an indirect measure of brain activity underpinning their ongoing pain experiences.
methodsPsychometric data were collected using validated questionnaires. Quantitative estimates of rCBF were acquired using pseudo-continuous arterial spin-labelled functional magnetic resonance imaging.
resultsTwo principal components were identified that accounted for 73% of data variance; one related to pain scores and a second to psychological traits. Voxel-wise multiple regression analysis revealed a significant negative association between the 'pain score' component and rCBF to a right temporal lobe cluster, including the amygdala and the parahippocampal cortex.
conclusionWe suggest this association may represent a coping mechanism that aims to reduce fear-related pain-anxiety. Further investigation of central brain processing mechanisms in osteoarthritis-related pain may offer insights into more effective therapeutic strategies. SIGNIFICANCE: This study demonstrates that dimension reduction using PCA allows insight into pain perception and its affective components in relation to brain activation patterns in patients with painful hand osteoarthritis.
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