Evidence map›Paper›PMID 29520865›Full record

ArticleGlia2018

Schwann cells regulate sensory neuron gene expression before and after peripheral nerve injury.

Gunnar Poplawski, Tetsuhiro Ishikawa, Coralie Brifault, Corinne Lee-Kubli, Robert Regestam, Kenneth W Henry, Yasuhiro Shiga, HyoJun Kwon, Seiji Ohtori, Steven L Gonias and 1 more

Abstract read
In one paragraph

Article in Glia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 49 citations in OpenAlex.

  1. Review
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  14. Silencing the enhancer of zeste homologue 2,Neural regeneration research · 2022
    Article
  15. Peripheral mechanisms of chronic pain.Medical review (2021) · 2022
    Review
  16. α1-Antitrypsin derived SP16 peptide demonstrates efficacy in rodent models of acute and neuropathic pain.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022
    Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Gunnar PoplawskiDepartment of Neurosciences, UCSD, La Jolla, California.
Tetsuhiro IshikawaDepartment of Anesthesiology, UCSD, La Jolla, California.
Coralie BrifaultDepartment of Pathology, UCSD, La Jolla, California.
Corinne Lee-KubliDepartment of Neurosciences, UCSD, La Jolla, California.
Robert RegestamDepartment of Anesthesiology, UCSD, La Jolla, California.
Kenneth W HenryDepartment of Anesthesiology, UCSD, La Jolla, California.
Yasuhiro ShigaDepartment of Anesthesiology, UCSD, La Jolla, California.
HyoJun KwonDepartment of Anesthesiology, UCSD, La Jolla, California.
Seiji OhtoriDepartment of Orthopedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Steven L GoniasDepartment of Pathology, UCSD, La Jolla, California.
Wendy M CampanaProgram in Neuroscience, UCSD, La Jolla, California.ORCID 0000-0002-9039-1396
University of California San Diego · USChiba University · JP

Funding

U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0M
Regulation of Inflammation by the Fibrinolytic SystemR01HL136395 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GONIAS, STEVEN L. · 2017 to 2025
$3.5M
LRP-1 is a multifunctional regulator during peripheral nerve injury and pain.R01NS057456 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CAMPANA, WENDY M. · 2008 to 2012
$1.7M
Schwann Cell NMDA Receptor in PNS InjuryR01NS097590 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CAMPANA, WENDY M., GONIAS, STEVEN L. · 2017 to 2020
$1.4M
NHLBI NIH HHS HL136395NINDS NIH HHS P30 NS047101NINDS NIH HHS R01 NS057456NINDS NIH HHS R01 NS097590
6 · The paper itself

Abstract

Sensory neurons in the PNS demonstrate substantial capacity for regeneration following injury. Recent studies have identified changes in the transcriptome of sensory neurons, which are instrumental for axon regeneration. The role of Schwann cells (SCs) in mediating these changes remains undefined. We tested the hypothesis that SCs regulate expression of genes in sensory neurons before and after PNS injury by comparing mice in which LDL Receptor-related Protein-1 (LRP1) is deleted in SCs (scLRP1

Indexed as

AnimalsCells, CulturedGene ExpressionMice, Inbred C57BLMice, TransgenicNerve RegenerationNeuronal OutgrowthPeripheral Nerve InjuriesSchwann CellsSciatic NerveSciatic NeuropathySensory Receptor Cellsaxonal growthDRGLRP1painperipheral nerveregeneration associated genes (RAGs)Schwann cell

Identifiers

PMID29520865
PMCPMC6129445
OpenAlexW2793938072

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.