ArticleJournal of periodontology2018
Insulin resistance predicts the risk of gingival/periodontal inflammation.
Article in Journal of periodontology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Review
- Protective effect of high-density lipoprotein in infective endocarditis patients after valve surgery.International journal of cardiology. Heart & vasculature · 2025Article
- Regulating effect of dietary antioxidant quality on association between estimated glucose disposal rate and moderate to severe periodontitis.Frontiers in nutrition · 2025Article
- The bidirectional association between diabetes and periodontitis, from basic to clinical.The Japanese dental science review · 2024Review
- Periodontal Disease and Metabolic Syndrome in Women at Prior High Risk for Gestational Diabetes.Clinical and experimental dental research · 2024Article
- Association of Urine (pH < 5.5) with Community Periodontal Index (CPI) and the Number of Remaining Teeth in Korean Adults: A Cross-Sectional Study Using Data from Korea National Health and Nutrition Examination Survey 2016-2018.Healthcare (Basel, Switzerland) · 2024Article
- Association Between Weight-Adjusted Waist Index and Periodontitis: A Cross-Sectional Study and Mediation Analysis.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Periodontal Disease, Local and Systemic Inflammation in Puerto Ricans with Type 2 Diabetes Mellitus.Biomedicines · 2023Article
- Systemic Inflammation, Endothelial Function, and Risk of Periodontitis in Overweight/Obese Adults.Biomedicines · 2023Article
- Glycemic and Insulin Status in Periodontitis Patients using the Homeostasis Model Assessment (HOMA): A Pilot Study.Oral health & preventive dentistry · 2023Article
- Hispanic adults with type 2 diabetes mellitus using lipid-lowering agents have better periodontal health than non-users.Therapeutic advances in chronic disease · 2023Article
- Effect of inflammation on bones in diabetic patients with periodontitis via RANKL/OPG system-A review.Journal of diabetes and metabolic disorders · 2022Review
- Impact of Impaired Glucose Metabolism on Periodontitis Progression over Three Years.Dentistry journal · 2022Article
- Salivary Cytokine Biomarker Concentrations in Relation to Obesity and Periodontitis.Journal of clinical medicine · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectivesEvaluate whether insulin resistance (IR) predicts the risk of oral inflammation, assessed as the number of sites with bleeding on probing (BOP) and number of teeth with probing pocket depths (PPD) ≥ 4 mm and BOP.
methodsData on 870 overweight/obese diabetes free adults, aged 40-65 years from the San Juan Overweight Adults Longitudinal Study over a three-year period, was analyzed. Baseline IR, assessed using the Homeostasis Model Assessment of IR (HOMA-IR) index, was divided into tertiles. BOP was assessed at buccal and lingual sites, and PPD at six sites per tooth. Negative binomial regression was used to estimate the risk ratios (RRs) for oral inflammation adjusted for baseline age, gender, smoking status, alcohol intake, education, physical activity, waist circumference, mean plaque index, and baseline number of sites with BOP, or number of teeth with PPD≥4 mm and BOP. The potential impact of tertiles of serum TNF-α and adiponectin on the IR-oral inflammation association was also assessed in a subsample of 597 participants.
resultsParticipants in the highest HOMA-IR tertile at baseline had significantly higher numbers of sites with BOP [RR = 1.19, 95% confidence interval (CI): 1.03-1.36] and number of teeth with PPD ≥ 4 mm and BOP (RR = 1.39, 95% CI: 1.09-1.78) at follow-up, compared with individuals in the lower two HOMA-IR tertiles. Neither TNF-α nor adiponectin confounded the associations.
conclusionIR significantly predicts gingival/periodontal inflammation in this population.
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