Evidence map›Paper›PMID 29520738›Full record

ArticleJournal of inherited metabolic disease2018

Tetrahydrobiopterin treatment reduces brain L-Phe but only partially improves serotonin in hyperphenylalaninemic ENU1/2 mice.

Tanja Scherer, Gabriella Allegri, Christineh N Sarkissian, Ming Ying, Hiu Man Grisch-Chan, Anahita Rassi, Shelley R Winn, Cary O Harding, Aurora Martinez, Beat Thöny

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of inherited metabolic disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 4 countries.

Tanja SchererDepartment of Pediatrics, Divisions of Metabolism and of Clinical Chemistry and Biochemistry, University of Zürich, Zürich, Switzerland.
Gabriella AllegriDepartment of Pediatrics, Divisions of Metabolism and of Clinical Chemistry and Biochemistry, University of Zürich, Zürich, Switzerland.
Christineh N SarkissianDepartment of Biology, McGill University, Montreal, QC, H3A 1B1, Canada.
Ming YingDepartment of Biomedicine and K.G. Jebsen Centre for Neuropsychiatric Disorders, University of Bergen, Bergen, Norway.
Hiu Man Grisch-ChanDepartment of Pediatrics, Divisions of Metabolism and of Clinical Chemistry and Biochemistry, University of Zürich, Zürich, Switzerland.
Anahita RassiDepartment of Pediatrics, Divisions of Metabolism and of Clinical Chemistry and Biochemistry, University of Zürich, Zürich, Switzerland.
Shelley R WinnDepartment of Molecular and Medical Genetics, School of Medicine, Oregon Science & Health University, Portland, OR, USA.
Cary O HardingDepartment of Molecular and Medical Genetics, School of Medicine, Oregon Science & Health University, Portland, OR, USA.
Aurora MartinezDepartment of Biomedicine and K.G. Jebsen Centre for Neuropsychiatric Disorders, University of Bergen, Bergen, Norway. aurora.martinez@uib.no.
Beat ThönyDepartment of Pediatrics, Divisions of Metabolism and of Clinical Chemistry and Biochemistry, University of Zürich, Zürich, Switzerland. beat.thony@kispi.uzh.ch.ORCID 0000-0002-5001-086X
University of Zurich · CHOregon Health & Science University · USUniversity of Bergen · NOMcGill University · CA

Funding

Novel therapy for monoamine neurotransmitter deficiency in PKUR01NS080866 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI HARDING, CARY O. · 2012 to 2020
$3.3M
NINDS NIH HHS R01 NS080866
6 · The paper itself

Abstract

Hyperphenylalaninemia (HPA) caused by hepatic phenylalanine hydroxylase (PAH) deficiency has severe consequences on brain monoamine neurotransmitter metabolism. We have studied monoamine neurotransmitter status and the effect of tetrahydrobiopterin (BH

Indexed as

AnimalsBiopterinsBrainDisease Models, AnimalDopamineHumansMiceMice, Mutant StrainsNeurotransmitter AgentsPhenylalaninePhenylalanine HydroxylasePhenylketonuriasSerotoninTryptophan HydroxylaseTyrosine 3-MonooxygenaseBiopterinsDopamineNeurotransmitter AgentsPhenylalaninePhenylalanine HydroxylasesapropterinSerotoninTryptophan HydroxylaseTyrosine 3-MonooxygenaseGTP cyclohydrolase (GTPCH) and GTP cyclohydrolase feedback-regulatory protein (GFRP)Monoamine neurotransmitterTryptophan hydroxylase 2Tyrosine hydroxylase

Identifiers

PMID29520738
PMCPMC6041158
OpenAlexW2791554105

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.