ArticleNeuroradiology2018
Hemodynamic vascular biomarkers for initiation of paraclinoid internal carotid artery aneurysms using patient-specific computational fluid dynamic simulation based on magnetic resonance imaging.
Article in Neuroradiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 16 citations in OpenAlex.
- Hemodynamic Features of Offending Vessels in Primary Hemifacial Spasm: A Computational Fluid Dynamics Study.Annals of biomedical engineering · 2026Article
- Amplification of Secondary Flow at the Initiation Site of Intracranial Sidewall Aneurysms.Cardiovascular engineering and technology · 2025Article
- Verifying the Accuracy of Hemodynamic Analysis Using High Spatial Resolution 3D Phase-contrast MR Imaging on a 7T MR System: Comparison with a 3T System.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025Article
- Case Report: Dynamic Changes in Hemodynamics During the Formation and Progression of Intracranial Aneurysms.Frontiers in cardiovascular medicine · 2021Article
- 4D Flow when and how?La Radiologia medica · 2020Review
- Hemodynamic Changes in the Carotid Artery after Infusion of Normal Saline Using Computational Fluid Dynamics.Diagnostics (Basel, Switzerland) · 2020Article
- Factors influencing blood flow resistance from a large internal carotid artery aneurysm revealed by a computational fluid dynamics model.Nagoya journal of medical science · 2019Article
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Authors and funding
9 authors at 6 institutions in 1 country.
Funding
Abstract
purposeWe performed computational fluid dynamics (CFD) for patients with and without paraclinoid internal carotid artery (ICA) aneurysms to evaluate the distribution of vascular biomarkers at the aneurysm initiation sites of the paraclinoid ICA.
methodsThis study included 35 patients who were followed up for aneurysms using 3D time of flight (TOF) magnetic resonance angiography (MRA) and 3D cine phase-contrast MR imaging. Fifteen affected ICAs were included in group A with the 15 unaffected contralateral ICAs in group B. Thirty-three out of 40 paraclinoid ICAs free of aneurysms and arteriosclerotic lesions were included in group C. We deleted the aneurysms in group A based on the 3D TOF MRA dataset. We performed CFD based on MR data set and obtained wall shear stress (WSS), its derivatives, and streamlines. We qualitatively evaluated their distributions at and near the intracranial aneurysm initiation site among three groups. We also calculated and compared the normalized highest (nh-) WSS and nh-spatial WSS gradient (SWSSG) around the paraclinoid ICA among three groups.
resultsHigh WSS and SWSSG distribution were observed at and near the aneurysm initiation site in group A. High WSS and SWSSG were also observed at similar locations in group B and group C. However, nh-WSS and nh-SWSSG were significantly higher in group A than in group C, and nh-SWSSG was significantly higher in group A than in group B.
conclusionOur findings indicated that nh-WSS and nh-SWSSG were good biomarkers for aneurysm initiation in the paraclinoid ICA.
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