Evidence map›Paper›PMID 29520587›Full record

ArticleAAPS PharmSciTech2018

P-glycoprotein Restricts Ocular Penetration of Loperamide across the Blood-Ocular Barriers: a Comparative Study in Mdr1a Knock-out and Wild Type Sprague Dawley Rats.

Akshaya Tatke, Karthik Yadav Janga, Bharathi Avula, XiangDi Wang, Monica M Jablonski, Ikhlas A Khan, Soumyajit Majumdar

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in AAPS PharmSciTech, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Akshaya TatkeDepartment of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, Oxford, Mississippi, USA.
Karthik Yadav JangaDepartment of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, Oxford, Mississippi, USA.
Bharathi AvulaNational Center for Natural Products Research, The University of Mississippi, Oxford, Mississippi, USA.
XiangDi WangDepartment of Ophthalmology, Hamilton Eye Institute, The University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Monica M JablonskiDepartment of Ophthalmology, Hamilton Eye Institute, The University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Ikhlas A KhanNational Center for Natural Products Research, The University of Mississippi, Oxford, Mississippi, USA.
Soumyajit MajumdarDepartment of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, Oxford, Mississippi, USA. majumso@olemiss.edu.
University of Mississippi · USUniversity of Tennessee Health Science Center · US

Funding

Evaluation and Inhibition of Efflux Pumps Expressed on the Blood Ocular BarrierR01EY022120 · NEI · UNIVERSITY OF MISSISSIPPI · PI MAJUMDAR, SOUMYAJIT · 2015 to 2018
$1.5M
NEI NIH HHS R01 EY022120
6 · The paper itself

Abstract

The current research was undertaken to determine the existence and magnitude of P-glycoprotein (P-gp) expression on the blood-ocular barriers by studying the ocular penetration of loperamide, a specific P-gp substrate, in P-gp (Mdr1a) knock-out (KO) and wild type (WT) Sprague Dawley rats. A clear, stable, sterile solution of loperamide (1 mg/mL), for intravenous administration, was formulated and evaluated. Ocular distribution was studied in P-gp KO and WT rats following intravenous administration of loperamide (at two doses). The drug levels in plasma, aqueous humor (AH), and vitreous humor (VH) samples were determined with the aid of UHPLC-Q-TOF-MS/MS, and the AH/plasma (D

Indexed as

AnimalsATP Binding Cassette Transporter, Subfamily BATP Binding Cassette Transporter, Subfamily B, Member 1BrainElectroretinographyLoperamideMaleRatsRats, Sprague-DawleyRats, TransgenicRetinaTandem Mass SpectrometryATP Binding Cassette Transporter, Subfamily BATP Binding Cassette Transporter, Subfamily B, Member 1Loperamidemultidrug resistance protein 3blood-ocular barrierselectroretinographyocular distributionP-glycoproteinretinal pigmented epithelium

Identifiers

PMID29520587
PMCPMC7325844
OpenAlexW2793505758

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.