ReviewFrontiers in pediatrics2018
The Epidemic of Neonatal Abstinence Syndrome, Historical References of Its' Origins, Assessment, and Management.
Review in Frontiers in pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 57 citations in OpenAlex.
- Treatment of opioid withdrawal in neonates with morphine, phenobarbital, or chlorpromazine: a randomized double-blind trial.European journal of pediatrics · 2020Trial
- Physiologic dysregulation in newborns with prenatal opioid exposure: Cardiac, respiratory and movement activity.Neurotoxicology and teratologyTrial
- Analgosedation in Neonatal Intensive Care: Current Strategies, Challenges, and Future Perspectives.Life (Basel, Switzerland) · 2026Review
- A comparative study of two scoring systems for the assessment of neonatal abstinence syndrome.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Longitudinal academic achievement in children with a history of neonatal abstinence syndrome: a retrospective observational cohort study.Lancet regional health. Americas · 2026Article
- Therapeutic Update in Neonatal Opioid Withdrawal Syndrome: Comparative Effectiveness of Pharmacological Treatments and the ESC Assessment Model. A Systematic Review.Health science reports · 2026Review
- Prenatal Opioid Exposure and Neonatal Opioid Withdrawal Syndrome.Advances in experimental medicine and biology · 2026Review
- Fentanyl exposure during preconception and gestation permanently dysregulates endogenous opioid peptides and sympathoadrenal-medullary axis in the offspring.Clinical science (London, England : 1979) · 2025Article
- Beyond a simple cause and effect relationship: Exploring the long-term outcomes of children prenatally exposed to opioids and other substances.Seminars in perinatology · 2025Review
- Inpatient Growth in Infants Requiring Pharmacologic Treatment for Neonatal Opioid Withdrawal Syndrome.International journal of pediatrics · 2024Article
- Neonatal abstinence syndrome and infant mortality and morbidity: a population-based study.Frontiers in pediatrics · 2024Article
- Postnatal oxytocin treatment improves survival and neurodevelopmental outcomes in an animal model of neonatal abstinence syndrome.Comprehensive psychoneuroendocrinology · 2022Article
- A retrospective, observational study on medication for opioid use disorder during pregnancy and risk for neonatal abstinence syndrome.Family practice · 2022Observational
- Neonaticides in the United States-2008-2017.Academic forensic pathology · 2022Article
- Establishing evidence-based pharmacologic treatments for neonatal abstinence syndrome: A retrospective case study.Journal of clinical and translational science · 2022Article
- Neonatal Outcomes after Combined Opioid and Nicotine Exposure in Utero: A Scoping Review.International journal of environmental research and public health · 2021Article
- Disparities in neonatal abstinence syndrome and health insurance status: A statewide study using non-claims real-time surveillance data.Paediatric and perinatal epidemiology · 2021Article
- The Challenges to Promoting Attachment for Hospitalised Infants with NAS.Children (Basel, Switzerland) · 2021Article
- Article
- Opioid Addiction/Pregnancy and Neonatal Abstinence Syndrome (NAS): A Preliminary Open-Label Study of Buprenorphine Maintenance and Drug Use Targeted Psychotherapy (DUST) on Cessation of Addictive Drug Use.Frontiers in psychiatry · 2020Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neonatal abstinence syndrome (NAS) refers to a constellation of signs that are present in some newborn infants resulting from the abrupt cessation of passive transfer of maternal opioids used during pregnancy. The classic NAS refers to infants born to mothers who used opioids during pregnancy, but the term has broadened to include infants whose mothers have used or abused other psychoactive substances during pregnancy that contribute to the expression of the syndrome. Pregnant women who use opioids do so illicitly, and/or as medically prescribed for pain relief, and/or as medication assisted treatment for opioid dependence. The first case of NAS in infants and the subsequent treatment (or lack thereof) was reported in 1875 and was called Congenital Morphinism. By 2012, the incidence of NAS increased to more than 30 per 1,000 hospital live births, along with an increase in the number of infants being treated pharmacologically for NAS, resulting in an increase in the length of stay and healthcare expenses. We present historical references on NAS, the various factors and events that led to its increasing prevalence and today's current epidemic. We also review the current tools to assess infants with NAS and treatment options in its management.
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