Evidence map›Paper›PMID 29520331›Full record

ArticleTremor and other hyperkinetic movements (New York, N.Y.)2018

Reversal of Status Dystonicus after Relocation of Pallidal Electrodes in DYT6 Generalized Dystonia.

D L Marinus Oterdoom, Martje E van Egmond, Luisa Cassini Ascencao, J Marc C van Dijk, Assel Saryyeva, Martijn Beudel, Joachim Runge, Tom J de Koning, Mahmoud Abdallat, Hendriekje Eggink and 2 more

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In one paragraph

Article in Tremor and other hyperkinetic movements (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. ArXiv · 2025
    Article
  5. Generalized Dystonia Due to a PathogenicTremor and other hyperkinetic movements (New York, N.Y.) · 2023
    Article
  6. Review
  7. Article
  8. Review
  9. Risk Factor Genes in Patients with Dystonia: A Comprehensive Review.Tremor and other hyperkinetic movements (New York, N.Y.) · 2018
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

D L Marinus OterdoomDepartment of Neurosurgery, University of Groningen, University Medical Center Groningen, the Netherlands.
Martje E van EgmondDepartment of Neurology, University of Groningen, University Medical Center Groningen, the Netherlands.
Luisa Cassini AscencaoDepartment of Neurosurgery, Hannover Medical School, Germany.
J Marc C van DijkDepartment of Neurosurgery, University of Groningen, University Medical Center Groningen, the Netherlands.
Assel SaryyevaDepartment of Neurosurgery, Hannover Medical School, Germany.
Martijn BeudelDepartment of Neurology, University of Groningen, University Medical Center Groningen, the Netherlands.
Joachim RungeDepartment of Neurosurgery, Hannover Medical School, Germany.
Tom J de KoningDepartment of Pediatrics, University of Groningen, University Medical Center Groningen, the Netherlands.
Mahmoud AbdallatDepartment of Neurosurgery, Hannover Medical School, Germany.
Hendriekje EgginkDepartment of Neurology, University of Groningen, University Medical Center Groningen, the Netherlands.
Marina A J TijssenDepartment of Neurology, University of Groningen, University Medical Center Groningen, the Netherlands.
Joachim K KraussDepartment of Neurosurgery, Hannover Medical School, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: DYT6 dystonia can have an unpredictable clinical course and the result of deep brain stimulation (DBS) of the internal part of the globus pallidus (GPi) is known to be less robust than in other forms of autosomal dominant dystonia. Patients who had previous stereotactic surgery with insufficient clinical benefit form a particular challenge with very limited other treatment options available. Case Report: A pediatric DYT6 patient unexpectedly deteriorated to status dystonicus 1 year after GPi DBS implantation with good initial clinical response. After repositioning the DBS electrodes the status dystonicus resolved. Discussion: This case study demonstrates that medication-resistant status dystonicus in DYT6 dystonia can be reversed by relocation of pallidal electrodes. This case highlights that repositioning of DBS electrodes may be considered in patients with status dystonicus, especially when the electrode position is not optimal, even after an initial clinical response to DBS.

Indexed as

Deep Brain StimulationApoptosis Regulatory ProteinsChildDNA-Binding ProteinsDystoniaDystonic DisordersGlobus PallidusHumansMaleNuclear ProteinsReoperationApoptosis Regulatory ProteinsDNA-Binding ProteinsNuclear ProteinsTHAP1 protein, humandeep brain stimulationDYT6Status dystonicus

Identifiers

PMID29520331
PMCPMC5840317

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.