ArticleJournal of behavioral and brain science2012
Influence of Iron Deficiency on Olfactory Behavior in Weanling Rats.
Article in Journal of behavioral and brain science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- A systematic-review of olfactory deficits in neurodevelopmental disorders: From mouse to human.Neuroscience and biobehavioral reviews · 2021Pooled it
- Olfactory function and an explanatory model of pica revealed through a case report.Journal of eating disorders · 2026Article
- Relationship Between "Geosminophilia" (Liking the Smell of Earth) and Pica in Patients With Iron Deficiency.Cureus · 2023Article
- Desiderosmia: a manifestation of iron deficiency in pregnancy.BMJ case reports · 2022Article
- Recognizing the unusual findings: Cases of desiderosmia.Clinical case reports · 2019Article
- Metal concentrations and distributions in the human olfactory bulb in Parkinson's disease.Scientific reports · 2017Article
- Postnatal Iron Deficiency Alters Brain Development in Piglets.The Journal of nutrition · 2016Article
- Pica for Uncooked Basmati Rice in Two Women with Iron Deficiency and a Review of Ryzophagia.Case reports in medicine · 2016Article
- Loss of NEIL1 causes defects in olfactory function in mice.Neurobiology of aging · 2015Article
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
Chronically high occupational exposure to airborne metals like iron can impair olfactory function, but little is known about how low iron status modifies olfactory behavior. To investigate the influence of body iron status, weanling rats were fed a diet with low iron content (4 - 7 ppm) to induce iron deficiency anemia and olfactory behavior was compared to control rats fed an isocaloric diet sufficient in iron (210 - 220 ppm). Iron-deficient rats had prolonged exploratory time for attractive odorants in behavioral olfactory habituation/dis-habituation tests, olfactory preference tests and olfactory sensitivity tests compared with control rats. No significant differences were observed for aversive odorants between the two groups. These findings suggest that iron-dependent functions may be involved in controlling and processing of olfactory signal transduction via self and lateral inhibition such that odorant signal remains stronger for longer times prolonging exploratory activity on attractive odorants in the behavioral tests. These findings establish that iron deficiency can modify olfactory behavior.
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Registered trials
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