ArticleBeilstein journal of organic chemistry2018
Continuous multistep synthesis of 2-(azidomethyl)oxazoles.
Article in Beilstein journal of organic chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- The use of phosphotriesterase in the synthesis of enantiomerically pure ProTide prodrugs.Chemico-biological interactions · 2025Review
- Telescoped Flow Synthesis of Azacyclic Scaffolds Exploiting the Chromoselective Photolysis of Vinyl Azides and Azirines.Chemistry (Weinheim an der Bergstrasse, Germany) · 2024Article
- A sustainable strategy for the straightforward preparation of 2Beilstein journal of organic chemistry · 2021Article
- Access to highly substituted oxazoles by the reaction of α-azidochalcone with potassium thiocyanate.Beilstein journal of organic chemistry · 2020Article
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Authors and funding
5 authors.
Funding
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Abstract
An efficient three-step protocol was developed to produce 2-(azidomethyl)oxazoles from vinyl azides in a continuous-flow process. The general synthetic strategy involves a thermolysis of vinyl azides to generate azirines, which react with bromoacetyl bromide to provide 2-(bromomethyl)oxazoles. The latter compounds are versatile building blocks for nucleophilic displacement reactions as demonstrated by their subsequent treatment with NaN
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