ArticleRadiology and oncology2018
The Influence of Genetic Variability on the Risk of Developing Malignant Mesothelioma.
Article in Radiology and oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Genetic variability of immune checkpoints in asbestos-related diseases.Radiology and oncology · 2026Article
- Genetic variability ofRadiology and oncology · 2025Article
- Current causes of mesothelioma: how has the asbestos ban changed the perspective?Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia · 2023Review
- The Genes-Stemness-Secretome Interplay in Malignant Pleural Mesothelioma: Molecular Dynamics and Clinical Hints.International journal of molecular sciences · 2023Review
- The influence of genetic variability in IL1B and MIR146A on the risk of pleural plaques and malignant mesothelioma.Radiology and oncology · 2020Article
- NLRP3 and CARD8 polymorphisms influence risk for asbestos-related diseases.Journal of medical biochemistry · 2020Article
- Article
- The influence of genetic variability of DNA repair mechanisms on the risk of malignant mesothelioma.Radiology and oncology · 2019Article
- Genetic polymorphisms in aquaporin 1 as risk factors for malignant mesothelioma and biomarkers of response to cisplatin treatment.Radiology and oncology · 2019Article
- Matrix Metalloproteinases Polymorphisms as Baseline Risk Predictors in Malignant Pleural Mesothelioma.Radiology and oncology · 2018Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMalignant mesothelioma is a rare cancer with poor outcome, associated with asbestos exposure. Reactive oxygen species may play an important role in the mechanism of carcinogenesis; therefore, genetic variability in antioxidative defence may modify an individual's susceptibility to this cancer. This study investigated the influence of functional polymorphisms of PATIENTS AND
methodsIn total, 150 cases with malignant mesothelioma and 122 controls with no asbestos-related disease were genotyped for
resultsThe risk of malignant mesothelioma increased with smoking, odds ratio (OR) 9.30 [95% confidence interval (CI): 4.83-17.98] and slightly with age, OR 1.10 (95% CI: 1.08-1.14). Medium and high asbestos exposures represented 7-times higher risk of malignant mesothelioma compared to low exposure, OR 7.05 (95% CI 3.59-13.83).
conclusionsOur findings suggest a role of both genetic variability in antioxidative defence and repair as well as the impact of gene-gene interactions in the development of malignant mesothelioma. The results of this study could add to our understanding of pathogenesis of malignant mesothelioma and contribute to prevention and earlier diagnosis of this aggressive cancer.
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