Evidence map›Paper›PMID 29520140›Full record

ArticleInternational journal of nanomedicine2018

Theranostic pH-sensitive nanoparticles for highly efficient targeted delivery of doxorubicin for breast tumor treatment.

Changqie Pan, Yuqing Liu, Minyu Zhou, Wensheng Wang, Min Shi, Malcolm Xing, Wangjun Liao

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 65 citations in OpenAlex.

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  10. Drug delivery strategy in hepatocellular carcinoma therapy.Cell communication and signaling : CCS · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Changqie Pan *Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Yuqing Liu *Department of Mechanical Engineering.
Minyu ZhouDepartment of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Wensheng WangThe Imaging Center, 999 Brain Hospital, Guangzhou, China.
Min ShiDepartment of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Malcolm XingDepartment of Mechanical Engineering.
Wangjun LiaoDepartment of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Nanfang Hospital · CNChildren's Hospital Research Institute of Manitoba · CAGuangdong 999 Brain Hospital · CNUniversity of Manitoba · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A multifunctional theranostic nanoplatform integrated with environmental responses has been developed rapidly over the past few years as a novel treatment strategy for several solid tumors. We synthesized pH-sensitive poly(β-thiopropionate) nanoparticles with a supermagnetic core and folic acid (FA) conjugation (FA-doxorubicin-iron oxide nanoparticles [FA-DOX@ IONPs]) to deliver an antineoplastic drug, DOX, for the treatment of folate receptor (FR)-overexpressed breast cancer. In addition to an imaging function, the nanoparticles can release their payloads in response to an environment of pH 5, such as the acidic environment found in tumors. After chemical (

Indexed as

AnimalsAntibiotics, AntineoplasticBreast NeoplasmsCell Line, TumorDoxorubicinDrug Delivery SystemsFemaleFolate Receptors, GPI-AnchoredFolic AcidHumansHydrogen-Ion ConcentrationMagnetic Resonance ImagingMCF-7 CellsMice, Inbred BALB CNanoparticlesTheranostic NanomedicineAntibiotics, AntineoplasticDoxorubicinFolate Receptors, GPI-AnchoredFolic Acidbreast cancerfolate receptor targetingmagnetic nanoparticlepH sensitivitytheranostics

Identifiers

PMID29520140
PMCPMC5834183
OpenAlexW2790305060

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.