Evidence map›Paper›PMID 29520038›Full record

ArticleMolecular psychiatry2019

Problems in interpreting and using GWAS of conditional phenotypes illustrated by 'alcohol GWAS'.

Michael V Holmes, George Davey Smith

Abstract readLetterComment
In one paragraph

Article in Molecular psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  13. Genome-wide association for testis weight in the diversity outbred mouse population.Mammalian genome : official journal of the International Mammalian Genome Society · 2018
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Michael V HolmesMedical Research Council Population Health Research Unit, University of Oxford, Oxford, UK. michael.holmes@ndph.ox.ac.uk.
George Davey SmithMedical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 2BN, UK. KZ.Davey-Smith@bristol.ac.uk.

Funding

British Heart Foundation FS/18/23/33512Medical Research Council MC_UU_12013/1
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Biological Specimen BanksGenome-Wide Association StudyAlcohol DrinkingPhenotypeUnited Kingdom

Identifiers

PMID29520038
PMCPMC6004313

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.