ArticleMucosal immunology2018
Intestinal epithelial Caspase-8 signaling is essential to prevent necroptosis during Salmonella Typhimurium induced enteritis.
Article in Mucosal immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
37 citing papers in PubMed, 53 citations in OpenAlex.
- MAP4Ks drive cell death in response tomBio · 2026Article
- CHMP4C promotes pancreatic cancer progression by inhibiting necroptosis via the RIPK1/RIPK3/MLKL pathway.Journal of advanced research · 2025Article
- Article
- Role of polyamines in intestinal mucosal barrier function.Seminars in immunopathology · 2025Review
- PANoptosis in Bacterial Infections: A Double-Edged Sword Balancing Host Immunity and Pathogenesis.Pathogens (Basel, Switzerland) · 2025Review
- Role of necroptosis in pulpitis: integration of bacterial infection, immune imbalance, and oxidative stress.PeerJ · 2025Review
- Article
- A purified diet affects intestinal epithelial proliferation and barrier functions through gut microbial alterations.International immunology · 2024Article
- The Yin and Yang of pathogens and probiotics: interplay betweenFrontiers in microbiology · 2024Article
- PANoptosis in intestinal epithelium: its significance in inflammatory bowel disease and a potential novel therapeutic target for natural products.Frontiers in immunology · 2024Review
- LNCGM1082 in Gut Epithelial Cells Promotes Expulsion of Infected Epithelial Cells and Release of IL-18.ImmunoHorizons · 2024Article
- Exopolysaccharides of Lactobacillus rhamnosus GG ameliorate Salmonella typhimurium-induced intestinal inflammation via the TLR4/NF-κB/MAPK pathway.Journal of animal science and biotechnology · 2023Article
- Time-Lapse Imaging of Inflammasome-Dependent Cell Death and Extrusion in Enteroid-Derived Intestinal Epithelial Monolayers.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Regulated necrosis, a proinflammatory cell death, potentially counteracts pathogenic infections.Cell death & disease · 2022Review
- Cross-Talk Between the Intestinal Epithelium andFrontiers in microbiology · 2022Review
- STAT1 coordinates intestinal epithelial cell death during gastrointestinal infection upstream of Caspase-8.Mucosal immunology · 2022Article
- Chicken-Specific Kinome Analysis of Early Host Immune Signaling Pathways in the Cecum of Newly Hatched Chickens Infected WithFrontiers in cellular and infection microbiology · 2022Article
- The role of necroptosis in disease and treatment.MedComm · 2021Review
- A Modern-World View of Host-Microbiota-Pathogen Interactions.Journal of immunology (Baltimore, Md. : 1950) · 2021Review
- The Gut-Brain Axis in Inflammatory Bowel Disease-Current and Future Perspectives.International journal of molecular sciences · 2021Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although induction of host cell death is a pivotal step during bacteria-induced gastroenteritis, the molecular regulation remains to be fully characterized. To expand our knowledge, we investigated the role of the central cell death regulator Caspase-8 in response to Salmonella Typhimurium. Here, we uncovered that intestinal salmonellosis was associated with strong upregulation of members of the host cell death machinery in intestinal epithelial cells (IECs) as an early event, suggesting that elimination of infected IECs represents a host defense strategy. Indeed, Casp8
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.