SynthesisJournal of neurology, neurosurgery, and psychiatry2018
Systematic review and meta-analysis on outcome differences among patients with TICI2b versus TICI3 reperfusions: success revisited.
Synthesis in Journal of neurology, neurosurgery, and psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
80 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Impact of stroke imaging selection modality on endovascular thrombectomy outcomes in the early and extended time windows: A meta-analysis.Brain and behavior · 2024Pooled it
- Safety and efficacy of intravenous thrombolysis before mechanical thrombectomy in patients with atrial fibrillation.Systematic reviews · 2024Pooled it
- Safety and efficacy of intra-arterial fibrinolytics as adjunct to mechanical thrombectomy: a systematic review and meta-analysis of observational data.Journal of neurointerventional surgery · 2021Pooled it
- Infarct Growth despite Successful Endovascular Reperfusion in Acute Ischemic Stroke: A Meta-analysis.AJNR. American journal of neuroradiology · 2021Pooled it
- Mechanical Thrombectomy in Nonagenarians: a Systematic Review and Meta-analysis.Translational stroke research · 2021Pooled it
- Direct mechanical thrombectomy in tPA-ineligible and -eligible patients versus the bridging approach: a meta-analysis.Journal of neurointerventional surgery · 2019Pooled it
- Reperfusion-dependent treatment effects of thrombectomy in patients with large ischemic infarcts.International journal of stroke : official journal of the International Stroke Society · 2026Trial
- Trial
- One-year single-center experience with the Aperio thrombectomy device in large vessel occlusion in the anterior circulation: safety, efficacy, and clinical outcome.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Trial
- Article
- Thrombolysis in Cerebral Infarction (TICI) 2b Versus TICI 3 Reperfusion in Stroke Patients with Mild Symptoms.Clinical neuroradiology · 2026Article
- Global vasodilatation in the middle cerebral artery territory as a new imaging marker of poor outcome after endovascular thrombectomy.Neuroradiology · 2026Article
- Comprehensive Assessment of Arterial, Tissue, and Venous Collaterals for Evaluating the Infarct Growth Rate: The Multimodal Collateral Score.Annals of clinical and translational neurology · 2026Article
- The thrombectomy in limb ischemia score (TILI-Score): score proposal and results of an interobserver readability survey.The international journal of cardiovascular imaging · 2026Article
- Health Economic Impact of Incomplete Reperfusion Patterns After Endovascular Thrombectomy in Acute Ischemic Stroke.Clinical neuroradiology · 2026Article
- Revisiting Incomplete Tissue-Level Reperfusion Following Successful Thrombectomy for Acute Ischemic Stroke.Annals of neurology · 2026Review
- ASPECTS evolution after endovascular successful reperfusion in the early and extended time window.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026Article
- Impact of balloon guiding catheter in contact aspiration thrombectomy using large bore aspiration catheter for acute anterior circulation stroke patients: a case-control study.BMC neurology · 2026Article
- The Analysis of Periprocedural Complications in Mechanical Thrombectomy for Acute Occlusion of the Intracranial Artery.Journal of neuroendovascular therapy · 2026Article
- Ferroptosis and futile recanalization after mechanical thrombectomy in acute ischemic stroke: mechanisms, risk factors, predictive models and therapeutic interventions.Experimental biology and medicine (Maywood, N.J.) · 2026Review
20 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveA reperfusion quality of thrombolysis in cerebral infarction (TICI)≥2b has been set as the therapeutic angiography target for interventions in patients with acute ischaemic stroke. This study addresses whether the distinction between TICI2b and TICI3 reperfusions shows a clinically relevant difference on functional outcome.
methodsA systematic literature review and meta-analysis was carried out and presented in conformity with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses criteria to test the primary hypothesis that TICI2b and TICI3 reperfusions are associated with different rates of modified Rankin Scale (mRS) ≤2 at day 90. Secondary endpoints included rates of haemorrhagic transformations, mortality and excellent functional outcome (mRS ≤1). Summary estimates of ORs (sOR) with 95% CI were calculated using the inverse variance heterogeneity model accounting for multiple true effect sizes.
resultsFourteen studies on 2379 successfully reperfused patients were included (1131 TICI3, 1248 TICI2b). TICI3 reperfusions were associated with higher rates of functional independence (1.74, 95% CI 1.44 to 2.10) and excellent functional outcomes (2.01, 95% CI 1.60 to 2.53), also after including adjusted estimates. The safety profile of patients with TICI3 was superior, as demonstrated by lower rates of mortality (sOR 0.59, 95% CI 0.37 to 0.92) and symptomatic intracranial haemorrhages (sOR 0.42, 95% CI 0.25 to 0.71).
conclusionTICI3 reperfusions are associated with superior outcome and better safety profiles than TICI2b reperfusions. This effect seems to be independent of time and collaterals. As reperfusion quality is the most important modifiable predictor of patients' outcome, a more conservative definition of successful therapy and further evaluation of treatment approaches geared towards achieving TICI3 reperfusions are desirable.
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