Evidence map›Paper›PMID 29519849›Full record

Observational studyCirculation2018

Trends in Hospitalizations and Survival of Acute Decompensated Heart Failure in Four US Communities (2005-2014): ARIC Study Community Surveillance.

Patricia P Chang, Lisa M Wruck, Eyal Shahar, Joseph S Rossi, Laura R Loehr, Stuart D Russell, Sunil K Agarwal, Suma H Konety, Carlos J Rodriguez, Wayne D Rosamond

2 registry-linked trialsOpen access · bronzeAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Circulation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 120 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
120citing papers in PubMed, 1 pooled it
14.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05329727 unknown statusnot on this mapstarted 2022, after this paper: background citation

The Comparative Effectiveness Study Between ARNI and ACE Inhibitor/ARB Medication in Patient With Heart Failure With Reduced Ejection Fraction Using the Nationwide Population Based Real World Registry of Korean Heart Failure

TypeobservationalSponsorWonju Severance Christian HospitalRan2022 to 2025Enrolled1,000,000ConditionsHeart Failure, MortalityArmsAngiotensin receptor neprilysin inhibitor (ARNI), Renin-Angiotensin System Inhibitor (RAS inhibitor)
NCT06478277 recruitingnot on this mapstarted 2026, after this paper: background citation

The UK CARDIOvascular Immune-Mediated Inflammatory Diseases (CARDIO-IMID) Registry

Typeobservational_patient_registrySponsorUniversity of ManchesterRan2026 to 2028Enrolled600ConditionsCardiovascular Diseases, Immune-Mediated Inflammatory Diseases
3 · Its place in the literature

Who cites it

120 citing papers in PubMed, 1 synthesis or guideline pooled it, 217 citations in OpenAlex.

  1. Pooled it
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  13. ANMCO position paper: diagnosis and treatment of heart failure with preserved systolic function.European heart journal supplements : journal of the European Society of Cardiology · 2025
    Article
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  17. Temporal trends in acute decompensated heart failure outcomes: A single-center 11-year retrospective analysis.International journal of cardiology. Cardiovascular risk and prevention · 2024
    Article
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60 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Patricia P ChangDepartments of Medicine (P.P.C., J.S.R.) patricia_chang@med.unc.edu.
Lisa M WruckDuke Clinical Research Institute, Duke University, Durham, NC (L.M.W.).
Eyal ShaharDepartment of Epidemiology and Biostatistics, University of Arizona, Tucson (E.S.).
Joseph S RossiDepartments of Medicine (P.P.C., J.S.R.).
Laura R LoehrEpidemiology (L.R.L., W.D.R.), University of North Carolina, Chapel Hill.
Stuart D RussellDepartment of Medicine, Johns Hopkins University, Baltimore, MD (S.D.R.).
Sunil K AgarwalDepartment of Medicine, Mount Sinai Health Systems, New York (S.K.A.).
Suma H KonetyDepartment of Medicine, University of Minnesota, Minneapolis (S.H.K.).
Carlos J RodriguezDivision of Public Health Sciences, Wake Forest University, Winston-Salem, NC (C.J.R.).
Wayne D RosamondEpidemiology (L.R.L., W.D.R.), University of North Carolina, Chapel Hill.
University of North Carolina at Chapel Hill · USClinical Research Institute · USJohns Hopkins University · USMount Sinai Health System · USUniversity of Arizona · USUniversity of Minnesota · US

Funding

NHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012C
6 · The paper itself

Abstract

backgroundCommunity trends of acute decompensated heart failure (ADHF) in diverse populations may differ by race and sex.

methodsThe ARIC study (Atherosclerosis Risk in Communities) sampled heart failure-related hospitalizations (≥55 years of age) in 4 US communities from 2005 to 2014 using International Classification of Diseases, Ninth Revision, Clinical Modification codes. ADHF hospitalizations were validated by standardized physician review and computer algorithm, yielding 40 173 events after accounting for sampling design (unweighted n=8746).

resultsOf the ADHF hospitalizations, 50% had reduced ejection fraction, and 39% had preserved EF (HFpEF). HF with reduced ejection fraction was more common in black men and white men, whereas HFpEF was most common in white women. Average age-adjusted rates of ADHF were highest in blacks (38.1 per 1000 black men, 30.5 per 1000 black women), with rates differing by HF type and sex. ADHF rates increased over the 10 years (average annual percentage change: black women +4.3%, black men +3.7%, white women +1.9%, white men +2.6%), mostly reflecting more acute HFpEF. Age-adjusted 28-day and 1-year case fatality proportions were ≈10% and 30%, respectively, similar across race-sex groups and HF types. Only blacks showed decreased 1-year mortality over time (average annual percentage change: black women -5.4%, black men -4.6%), with rates differing by HF type (average annual percentage change: black women HFpEF -7.1%, black men HF with reduced ejection fraction -4.7%).

conclusionsBetween 2005 and 2014, trends in ADHF hospitalizations increased in 4 US communities, primarily driven by acute HFpEF. Survival at 1 year was poor regardless of EF but improved over time for black women and black men.

Indexed as

AgedAge FactorsBlack or African AmericanFemaleHealth Status DisparitiesHeart FailureHospital MortalityHumansMaleMiddle AgedOutcome and Process Assessment, Health CarePatient AdmissionRetrospective StudiesRisk FactorsSex FactorsStroke Volumeejection fractionepidemiologyheart failuremortalityrace

Identifiers

PMID29519849
PMCPMC6030442
OpenAlexW2791404777

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.