Evidence map›Paper›PMID 29519798›Full record

ArticleJournal of investigative medicine : the official publication of the American Federation for Clinical Research2018

Early activation of peripheral monocytes with hallmarks of M1 and M2 monocytic cells in excessive alcohol drinkers: a pilot study.

Crystal C Walline, Janice S Blum, Tobyn Linton, Darrin Mangiacarne, Suthat Liangpunsakul

Open access · greenAbstract read
In one paragraph

Article in Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Crystal C WallineDepartment of Biology, University of North Carolina, Pembroke, North Carolina, USA.
Janice S BlumDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Tobyn LintonFairbanks Drug and Alcohol Rehabilitation, Indianapolis, Indiana, USA.
Darrin MangiacarneFairbanks Drug and Alcohol Rehabilitation, Indianapolis, Indiana, USA.
Suthat LiangpunsakulDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Richard M. Fairbanks Foundation · USIndiana University School of MedicineRichard L. Roudebush VA Medical Center · USUniversity of North Carolina at Pembroke · US

Funding

Poxvirus Modulation of Immune ResponsesP01AI056097 · NIAID · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI BLUM, JANICE S · 2003 to 2010
$9.9M
Translational Research and Evolving Alcoholic hepatitis Treatment (TREAT-IU)U01AA021840 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI NAGA P CHALASANI, Olawale Ojo · 2012 to 2026
$8.1M
BASIC SCIENCE STUDIES ON GENE THERAPY OF BLOOD DISEASEST32HL007910 · NHLBI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Roland W. Herzog, Reuben Kapur · 1999 to 2026
$7.6M
Genetic risk factors for alcoholic cirrhosis - genome-wide case-control studyU01AA018389 · NIAAA · SOUTHERN CALIFORNIA INST FOR RES/EDUC · PI CORDELL, HEATHER JANE, DALY, ANN · 2011 to 2018
$3.0M
Novel biomarkers as a clinical tool for excessive alcohol use screeningR01AA025208 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI LIANGPUNSAKUL, SUTHAT, TU, WANZHU · 2016 to 2020
$1.7M
Sestrin3 in the pathogenesis of alcoholic and non-alcoholic fatty liver diseaseR01DK107682 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI DONG, X. CHARLIE, LIANGPUNSAKUL, SUTHAT · 2016 to 2019
$1.4M
Effect of ethanol on Kupffer cell/hepatocyte interactions and lipid metabolismK08AA016570 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI LIANGPUNSAKUL, SUTHAT · 2008 to 2012
$659k
Long noncoding RNAs in alcoholic liver diseaseR21AA024935 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI LIANGPUNSAKUL, SUTHAT, WANG, LI · 2016 to 2017
$431k
Genetic risk factors for alcoholic cirrhosis - genome-wide case-control studyR01AA018389 · NIAAA · SOUTHERN CALIFORNIA INST FOR RES/EDUC · PI CORDELL, HEATHER JANE, DALY, ANN · 2019 to 2019
$336k
Serum Proteomic Profiles as Biomarkers of Abusive Alcohol ConsumptionI01CX000361 · VA · RLR VA MEDICAL CENTER · PI LIANGPUNSAKUL, SUTHAT · 2012 to 2025
–
CSRD VA I01 CX000361NHLBI NIH HHS T32 HL007910NIAAA NIH HHS K08 AA016570NIAAA NIH HHS R01 AA025208NIAAA NIH HHS R21 AA024935NIAAA NIH HHS U01 AA018389NIAAA NIH HHS U01 AA021840NIAID NIH HHS P01 AI056097NIDDK NIH HHS R01 DK107682
6 · The paper itself

Abstract

Excessive drinking can lead to the development of immune dysfunction. Our aim is to investigate the effect of alcohol on immune activation from circulating peripheral blood monocytes in excessive drinkers (EDs). Twenty-two EDs and healthy controls were enrolled. Time line follow-back was used to quantify the amount of alcohol consumed in the past 30 days before enrollment. Peripheral blood-derived CD14

Indexed as

AdultAlcohol DrinkingCase-Control StudiesCohort StudiesFemaleHumansImmunity, InnateInterleukin-10Interleukin-6LipopolysaccharidesMaleMonocytesPilot ProjectsRNA, MessengerIL10 protein, humanInterleukin-10Interleukin-6LipopolysaccharidesRNA, Messengeralcohol drinkinginnate immune response

Identifiers

PMID29519798
PMCPMC5970049
OpenAlexW2791251949

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.