Evidence map›Paper›PMID 29519721›Full record

ArticleJournal of neuroimmunology2018

Low-dose NSAIDs reduce pain via macrophage targeted nanoemulsion delivery to neuroinflammation of the sciatic nerve in rat.

Jelena M Janjic, Kiran Vasudeva, Muzamil Saleem, Andrea Stevens, Lu Liu, Sravan Patel, John A Pollock

Abstract read
In one paragraph

Article in Journal of neuroimmunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 54 citations in OpenAlex.

  1. An underlying mechanism of bovine mastitis: PGEThe veterinary quarterly · 2026
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  3. TargetedImmunotherapy advances · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jelena M JanjicGraduate School of Pharmaceutical Sciences, School of Pharmacy, Duquesne University, Pittsburgh, PA 15282, United States; Chronic Pain Research Consortium, Duquesne University, Pittsburgh, PA 15282, United States. Electronic address: janjicj@duq.edu.
Kiran VasudevaChronic Pain Research Consortium, Duquesne University, Pittsburgh, PA 15282, United States; Department of Biological Sciences, Bayer School of Natural & Environmental Science, Duquesne University, Pittsburgh, PA 15282, United States. Electronic address: kvasudeva@tuskegee.edu.
Muzamil SaleemChronic Pain Research Consortium, Duquesne University, Pittsburgh, PA 15282, United States; Department of Biological Sciences, Bayer School of Natural & Environmental Science, Duquesne University, Pittsburgh, PA 15282, United States. Electronic address: saleemm@duq.edu.
Andrea StevensChronic Pain Research Consortium, Duquesne University, Pittsburgh, PA 15282, United States; Department of Biological Sciences, Bayer School of Natural & Environmental Science, Duquesne University, Pittsburgh, PA 15282, United States. Electronic address: steven10@duq.edu.
Lu LiuGraduate School of Pharmaceutical Sciences, School of Pharmacy, Duquesne University, Pittsburgh, PA 15282, United States; Chronic Pain Research Consortium, Duquesne University, Pittsburgh, PA 15282, United States. Electronic address: liul@duq.edu.
Sravan PatelGraduate School of Pharmaceutical Sciences, School of Pharmacy, Duquesne University, Pittsburgh, PA 15282, United States; Chronic Pain Research Consortium, Duquesne University, Pittsburgh, PA 15282, United States. Electronic address: patels10@mwri.magee.edu.
John A PollockChronic Pain Research Consortium, Duquesne University, Pittsburgh, PA 15282, United States; Department of Biological Sciences, Bayer School of Natural & Environmental Science, Duquesne University, Pittsburgh, PA 15282, United States. Electronic address: pollock@duq.edu.
Duquesne University · US

Funding

Multimodal (PET/MR/NIR) imaging supported drug delivery in inflammatory diseasesR21EB023104 · NIBIB · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ANDERSON, CAROLYN J., JANJIC, JELENA M · 2016 to 2017
$409k
Request for a Nikon A1 confocal microscopeS10OD019973 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WATKINS, SIMON C · 2015 to 2015
$358k
Theranostic Pain Nanomedicines: imaging inflammation, reducing pain and need for opioidsR21DA039621 · NIDA · DUQUESNE UNIVERSITY · PI JANJIC, JELENA M · 2015 to 2016
$328k
NIBIB NIH HHS R21 EB023104NIDA NIH HHS R21 DA039621NIH HHS S10 OD019973
6 · The paper itself

Abstract

Neuroinflammation involving macrophages elevates Prostaglandin E

Indexed as

AnimalsAnti-Inflammatory Agents, Non-SteroidalCelecoxibEmulsionsInjections, IntravenousMacrophagesMaleNanotechnologyNeuralgiaRatsRats, Sprague-DawleySciatic NerveAnti-Inflammatory Agents, Non-SteroidalCelecoxibEmulsions

Identifiers

PMID29519721
PMCPMC6056892
OpenAlexW2791833360

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.