ArticleThe Journal of pediatrics2018
Neurodevelopmental Outcome of Young Children with Biliary Atresia and Native Liver: Results from the ChiLDReN Study.
Article in The Journal of pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Childhood Liver Disease Research Network (ChiLDReN): A Prospective Database of Infants With Cholestasis
A Randomized, Double-Blinded, Placebo-Controlled Trial of Corticosteroid Therapy Following Portoenterostomy in Infants With Biliary Atresia
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Hypermanganesemia in Children With Liver and Portosystemic Circulation Disorders: A Systematic Review.Journal of paediatrics and child health · 2026Pooled it
- Comparison of different Kasai portoenterostomy techniques in the outcomes of biliary atresia: a systematic review and network meta-analysis.Pediatric surgery international · 2024Pooled it
- School readiness in children with early-onset chronic liver disease: a population-based linked data cohort in England.Archives of disease in childhood · 2026Article
- Article
- Initiating a paediatric living donor liver transplant program in a resource-challenged environment: outcomes and lessons learned.Pediatric surgery international · 2025Article
- Analysis of risk factors affecting psycho-behavioural development in children with short bowel syndrome.Pediatric surgery international · 2025Article
- Biliary atresia.Nature reviews. Disease primers · 2024Review
- Cognitive function of children with biliary atresia after primary living donor liver transplantation.BMC pediatrics · 2024Article
- Long-term clinical and socioeconomic outcomes of children with biliary atresia.JGH open : an open access journal of gastroenterology and hepatology · 2023Article
- Towards a model of biliary atresia - Pilot feasibility study in newborn piglets.Biochemistry and biophysics reports · 2023Article
- Early life growth and developmental trajectory in children with biliary atresia undergoing primary liver transplantation.Frontiers in pediatrics · 2023Article
- Biliary Atresia in Children: Update on Disease Mechanism, Therapies, and Patient Outcomes.Clinics in liver disease · 2022Review
- Cholestasis alters brain lipid and bile acid composition and compromises motor function in neonatal piglets.Physiological reports · 2022Article
- Identification of Impaired Executive Functioning after Pediatric Liver Transplantation Using Two Short and Easily Applicable Tests: Cognitive Functioning Module PedsQL and Children's Color Trail Test.Children (Basel, Switzerland) · 2021Article
- Recent advances in understanding biliary atresia.F1000Research · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 17 institutions in 2 countries.
Funding
Abstract
objectivesTo assess neurodevelopmental outcomes among participants with biliary atresia with their native liver at ages 12 months (group 1) and 24 months (group 2), and to evaluate variables predictive of neurodevelopmental impairment. STUDY
designParticipants enrolled in a prospective, longitudinal, multicenter study underwent neurodevelopmental testing with either the Bayley Scales of Infant Development, 2nd edition, or Bayley Scales of Infant and Toddler Development, 3rd edition. Scores (normative mean = 100 ± 15) were categorized as ≥100, 85-99, and <85 for χ
resultsThere were 148 children who completed 217 Bayley Scales of Infant and Toddler Development, 3rd edition, examinations (group 1, n = 132; group 2, n = 85). Neurodevelopmental score distributions significantly shifted downward compared with test norms at 1 and 2 years of age. Multivariate analysis identified ascites (OR, 3.17; P = .01) and low length z-scores at time of testing (OR, 0.70; P < .04) as risk factors for physical/motor impairment; low weight z-score (OR, 0.57; P = .001) and ascites (OR, 2.89; P = .01) for mental/cognitive/language impairment at 1 year of age. An unsuccessful hepatoportoenterostomy was predictive of both physical/motor (OR, 4.88; P < .02) and mental/cognitive/language impairment (OR, 4.76; P = .02) at 2 years of age.
conclusionParticipants with biliary atresia surviving with native livers after hepatoportoenterostomy are at increased risk for neurodevelopmental delays at 12 and 24 months of age. Those with unsuccessful hepatoportoenterostomy are >4 times more likely to have neurodevelopmental impairment compared with those with successful hepatoportoenterostomy. Growth delays and/or complications indicating advanced liver disease should alert clinicians to the risk for neurodevelopmental delays, and expedite appropriate interventions.
trial registrationClinicaltrials.gov: NCT00061828 and NCT00294684.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.