Evidence map›Paper›PMID 29519366›Full record

ArticleHematology, transfusion and cell therapy

Platelet count response to Helicobacter pylori eradication for idiopathic thrombocytopenic purpura in northeastern Brazil.

Alzira Maria de Castro Barbosa, Rosangela Albuquerque Ribeiro, Cícero Ígor Simões Moura Silva, Francisco Will Saraiva Cruz, Orleancio Gomes Ripardo de Azevedo, Maria Helena da Silva Pitombeira, Lucia Libanez Campelo Braga

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hematology, transfusion and cell therapy. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03629587 (Helicobacter Pylori and it's Hematological Impact), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03629587 completednot on this map

Helicobacter Pylori and it's Hematological Impact

TypeobservationalSponsorAssiut UniversityRan2016 to 2018Enrolled100ConditionsH Pylori Infection
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Prevalence of Helicobacter pylori cagA virulence factor and validation of serological tests in a population from Northeastern Brazil.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2025
    Article
  3. Article
  4. Article
  5. Children (Basel, Switzerland) · 2022
    Review
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Alzira Maria de Castro BarbosaUniversidade Federal do Ceará (UFC), Fortaleza, CE, Brazil.
Rosangela Albuquerque RibeiroCentro de Hematologia e Hemoterapia do Ceará (Hemoce), Fortaleza, CE, Brazil.
Cícero Ígor Simões Moura SilvaUniversidade Federal do Ceará (UFC), Fortaleza, CE, Brazil.
Francisco Will Saraiva CruzUniversidade Federal do Ceará (UFC), Fortaleza, CE, Brazil.
Orleancio Gomes Ripardo de AzevedoUniversidade Federal do Ceará (UFC), Fortaleza, CE, Brazil.
Maria Helena da Silva PitombeiraCentro de Hematologia e Hemoterapia do Ceará (Hemoce), Fortaleza, CE, Brazil.
Lucia Libanez Campelo BragaUniversidade Federal do Ceará (UFC), Fortaleza, CE, Brazil. Electronic address: lucialib@terra.com.br.
Universidade Federal do Ceará · BRFundação Hospitalar de Hematologia e Hemoterapia do Amazonas · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeveral studies have demonstrated that platelet counts in Helicobacter pylori-positive patients with chronic idiopathic thrombocytopenic purpura improved significantly after successful eradication of the infection. However, depending of the geographical region of the study the results have been highly divergent.

objectiveThe purpose of this study was to evaluate the effect of H. pylori eradication therapy on platelet count in a cohort of chronic idiopathic thrombocytopenic purpura patients from northeastern Brazil.

methodH. pylori status was determined in 28 chronic idiopathic thrombocytopenic purpura patients using the rapid urease test and histology. H. pylori-positive patients received standard triple therapy for one week. The effect of the eradication therapy was evaluated using the 13C-urea breath test two to three months after treatment.

resultsThe prevalence of H. pylori infection was similar to that found in the general population. Twenty-two patients (78.5%) were H. pylori-positive. Fifteen were treated, 13 (86%) of whom successfully. At six months, 4/13 (30%) displayed increased platelet counts, which remained throughout follow-up (12 months). Platelet response was not associated to mean baseline platelet count, duration of chronic idiopathic thrombocytopenic purpura, gender, age, previous use of medication, or splenectomy.

conclusionsH. pylori eradication therapy showed relatively low platelet recovery rates, comparable with previous studies from southeastern Brazil. The effect of H. pylori eradication on platelet counts remained after one year of follow-up suggesting that treating H. pylori infection might be worthwhile in a subset of chronic idiopathic thrombocytopenic purpura patients.

Indexed as

Blood plateletHelicobacter pylori eradicationIdiopathic thrombocytopenic purpura

Identifiers

PMID29519366
PMCPMC6003102
OpenAlexW2769145299

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.