Evidence map›Paper›PMID 29518940›Full record

ArticleInternational journal of molecular sciences2018

A Three-MicroRNA Signature as a Potential Biomarker for the Early Detection of Oral Cancer.

Yi-An Chang, Shun-Long Weng, Shun-Fa Yang, Chih-Hung Chou, Wei-Chih Huang, Siang-Jyun Tu, Tzu-Hao Chang, Chien-Ning Huang, Yuh-Jyh Jong, Hsien-Da Huang

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
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  6. Article
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  8. Article
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  11. [Predictive Value of A miRNA Signature for Distant Metastasis in Lung Cancer].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2024
    Article
  12. Review
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  15. Oral Squamous Cell Carcinoma: Focus on Biomarkers for Screening.Journal of dentistry (Shiraz, Iran) · 2024
    Review
  16. Article
  17. Review
  18. Review
  19. The impact ofJournal of Cancer · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yi-An ChangDepartment of Biological Science and Technology, National Chiao Tung University, Hsinchu City 300, Taiwan. b8703126@gmail.com.
Shun-Long WengDepartment of Medicine, Mackay Medical College, New Taipei City 252, Taiwan. 4467@mmh.org.tw.
Shun-Fa YangDepartment of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan. ysf@csmu.edu.tw.ORCID 0000-0002-0365-7927
Chih-Hung ChouDepartment of Biological Science and Technology, National Chiao Tung University, Hsinchu City 300, Taiwan. chchou23@gmail.com.
Wei-Chih HuangDepartment of Biological Science and Technology, National Chiao Tung University, Hsinchu City 300, Taiwan. loveariddle.bi96g@g2.nctu.edu.tw.
Siang-Jyun TuInstitute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu City 300, Taiwan. mist0205@gmail.com.
Tzu-Hao ChangGraduate Institute of Biomedical Informatics, Taipei Medical University, Taipei 110, Taiwan. kevinchang@tmu.edu.tw.
Chien-Ning HuangInstitute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan. cshy049@csh.org.tw.
Yuh-Jyh JongDepartment of Biological Science and Technology, National Chiao Tung University, Hsinchu City 300, Taiwan. yjjongnctu@gmail.com.
Hsien-Da HuangDepartment of Biological Science and Technology, National Chiao Tung University, Hsinchu City 300, Taiwan. bryan@mail.nctu.edu.tw.ORCID 0000-0003-2857-7023

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral squamous cell carcinoma (OSCC) is often diagnosed at a late stage and may be malignantly transformed from oral leukoplakia (OL). This study aimed to identify potential plasma microRNAs (miRNAs) for the early detection of oral cancer. Plasma from normal, OL, and OSCC patients were evaluated. Small RNA sequencing was used to screen the differently expressed miRNAs among the groups. Next, these miRNAs were validated with individual samples by quantitative real-time polymerase chain reaction (qRT-PCR) assays in the training phase (

Indexed as

Biomarkers, TumorAdultAgedComputational BiologyEarly Detection of CancerFemaleGene Expression ProfilingHigh-Throughput Nucleotide SequencingHumansLogistic ModelsMaleMicroRNAsMiddle AgedMouth NeoplasmsNeoplasm StagingReproducibility of ResultsBiomarkers, TumorMicroRNAsbiomarkerearly diagnosisleukoplakiamiRNAoral cancer

Identifiers

PMID29518940
PMCPMC5877619

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.