Evidence map›Paper›PMID 29518918›Full record

ArticleCancers2018

Protein Biomarkers for Early Detection of Pancreatic Ductal Adenocarcinoma: Progress and Challenges.

Alex Root, Peter Allen, Paul Tempst, Kenneth Yu

Abstract read
In one paragraph

Article in Cancers, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Mucin Expression and Splicing Determine Novel Subtypes and Patient Mortality in Pancreatic Ductal Adenocarcinoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2021
    Article
  11. Review
  12. Article
  13. Article
  14. Molecular Diagnosis of Cystic Neoplasms of the Pancreas: a Review.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2020
    Review
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alex RootMolecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. roota@mskcc.org.
Peter AllenDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. allenp@mskcc.org.
Paul TempstMolecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. p-tempst@ski.mskcc.org.ORCID 0000-0002-6680-3987
Kenneth YuDepartment of Medicine, Weill Cornell Medical College, New York, NY 10065, USA. yuk1@mskcc.org.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Detection of Pre-Invasive Pancreatic Cysts Using Protein and Glycan BiomarkersU01CA152653 · NCI · VAN ANDEL RESEARCH INSTITUTE · PI ALLEN, PETER J, BRAND, RANDALL · 2010 to 2021
$5.8M
Biomarker validation for intraductal papillary mucinous neoplasms of the pancreasR01CA182076 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Peter J Allen · 2014 to 2026
$3.6M
Protein and proteolytic activity biomarkers of early stage pancreatic cancerR01CA208401 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI TEMPST, PAUL, YU, KENNETH H. · 2017 to 2021
$3.1M
Pharmacogenomic and circulating tumor cell approach to individualized treatment of pancreatic cancerR01CA202762 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI MCCARTHY, BRIAN J., YU, KENNETH H. · 2016 to 2020
$2.8M
Imaging drug uptake and distribution in chemoradiation therapy of pancreatic cancerR01CA194321 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI HUMM, JOHN L, PILLARSETTY, NAGAVARAKISHORE · 2016 to 2019
$2.7M
Immobilized protease activity tests for developing functional cancer biomarkers.R21CA174537 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI TEMPST, PAUL · 2014 to 2016
$764k
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA182076NCI NIH HHS R01 CA194321NCI NIH HHS R01 CA202762NCI NIH HHS R01 CA208401NCI NIH HHS R21 CA174537NCI NIH HHS U01 CA152653
6 · The paper itself

Abstract

Approximately 75% of patients with pancreatic ductal adenocarcinoma are diagnosed with advanced cancer, which cannot be safely resected. The most commonly used biomarker

Indexed as

biomarkersblood testCA19-9circulating DNAearly detectionELISAKRASmass spectrometrypancreatic ductal adenocarcinomathrombospondin

Identifiers

PMID29518918
PMCPMC5876642

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.