Evidence map›Paper›PMID 29518893›Full record

ArticleMolecules (Basel, Switzerland)2018

Antibacterial and Antifungal Activities of Poloxamer Micelles Containing Ceragenin CSA-131 on Ciliated Tissues.

Marjan M Hashemi, Brett S Holden, Maddison F Taylor, John Wilson, Jordan Coburn, Brian Hilton, Tania Nance, Shawn Gubler, Carl Genberg, Shenglou Deng and 1 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 28 citations in OpenAlex.

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  16. Susceptibility of Multidrug-Resistant Bacteria, Isolated from Water and Plants in Nigeria, to Ceragenins.International journal of environmental research and public health · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Marjan M HashemiDepartment of Chemistry and Biochemistry, Brigham Young University, C100 BNSN, Provo, UT 84602, USA. marjan.mhashemi@gmail.com.ORCID 0000-0003-4402-4410
Brett S HoldenDepartment of Chemistry and Biochemistry, Brigham Young University, C100 BNSN, Provo, UT 84602, USA. bholden222@yahoo.com.
Maddison F TaylorDepartment of Chemistry and Biochemistry, Brigham Young University, C100 BNSN, Provo, UT 84602, USA. maddifaytaylor@gmail.com.
John WilsonDepartment of Chemistry and Biochemistry, Brigham Young University, C100 BNSN, Provo, UT 84602, USA. johnmartinwilson@gmail.com.
Jordan CoburnDepartment of Chemistry and Biochemistry, Brigham Young University, C100 BNSN, Provo, UT 84602, USA. jccoburn2@gmail.com.ORCID 0000-0002-2038-0413
Brian HiltonDepartment of Chemistry and Biochemistry, Brigham Young University, C100 BNSN, Provo, UT 84602, USA. hiltonb93@gmail.com.
Tania NanceDepartment of Chemistry and Biochemistry, Brigham Young University, C100 BNSN, Provo, UT 84602, USA. tnance99@aol.com.
Shawn GublerDepartment of Chemistry and Biochemistry, Brigham Young University, C100 BNSN, Provo, UT 84602, USA. shgubler@gmail.com.
Carl GenbergN8 Medical, Dublin, OH 43017, USA. carlgenberg@n8medical.com.
Shenglou DengDepartment of Chemistry and Biochemistry, Brigham Young University, C100 BNSN, Provo, UT 84602, USA. shengloudeng@hotmail.com.
Paul B SavageDepartment of Chemistry and Biochemistry, Brigham Young University, C100 BNSN, Provo, UT 84602, USA. paul_savage@byu.edu.ORCID 0000-0002-4642-6109
Brigham Young University · USN8 Medical (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ceragenins were designed as non-peptide mimics of endogenous antimicrobial peptides, and they display broad-spectrum antibacterial and antifungal activities, including the ability to eradicate established biofilms. These features of ceragenins make them attractive potential therapeutics for persistent infections in the lung, including those associated with cystic fibrosis. A characteristic of an optimal therapeutic for use in the lungs and trachea is the exertion of potent antimicrobial activities without damaging the cilia that play a critical role in these tissues. In previous work, potent antimicrobial activities of ceragenin CSA-131 have been reported; however, we found in

Indexed as

MicellesAnimalsAnti-Bacterial AgentsAntifungal AgentsBacteriaBiofilmsCiliaFungiMicrobial Sensitivity TestsMolecular StructurePoloxamerRespiratory MucosaSteroidsSwineAnti-Bacterial AgentsAntifungal Agentsceragenin CSA-131MicellesPoloxamerSteroidsantibacterial activityantifungal activitybiofilmcerageninciliamicellespoloxamer

Identifiers

PMID29518893
PMCPMC6017798
OpenAlexW2793352869

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.