ArticleNeuroImage2018
Evolution of spatial and temporal features of functional brain networks across the lifespan.
Article in NeuroImage, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- A systematic review of global signal topography in aging, neuropsychiatric disorders, and cognitive task performance.Brain imaging and behavior · 2026Pooled it
- The older adult brain is less modular, more integrated, and less efficient at rest: A systematic review of large-scale resting-state functional brain networks in aging.Psychophysiology · 2023Pooled it
- Pooled it
- The effective connectome over a century of human life.Communications biology · 2025Article
- The effects of sex and age on movie-watching functional connectivity and movie clip classification.Brain structure & function · 2025Article
- Metrics for estimating individual-level changes in functional brain connectivity and their correspondence with topology changes.bioRxiv : the preprint server for biology · 2025Article
- Human lifespan changes in the brain's functional connectome.Nature neuroscience · 2025Article
- Dev-Atlas: A reference atlas of functional brain networks for typically developing adolescents.Developmental cognitive neuroscience · 2025Article
- The lifelong nonlinear development of spatial variability of brain signals.Communications biology · 2025Article
- Functional connectome through the human life span.bioRxiv : the preprint server for biology · 2024Article
- Systematic cross-sectional age-associations in global fMRI signal topography.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Age-related differences in structural and resting-state functional brain network organization across the adult lifespan: A cross-sectional study.Aging brain · 2024Article
- Brain signal variability and executive functions across the life span.Network neuroscience (Cambridge, Mass.) · 2024Article
- Functional network centrality indicates interactions between APOE4 and age across the clinical spectrum of Alzheimer's Disease.NeuroImage. Clinical · 2024Article
- Spatiotemporal dedifferentiation of the global brain signal topography along the adult lifespan.Human brain mapping · 2023Article
- Article
- Aging and Alzheimer's disease have dissociable effects on local and regional medial temporal lobe connectivity.Brain communications · 2023Article
- Controversies and progress on standardization of large-scale brain network nomenclature.Network neuroscience (Cambridge, Mass.) · 2023Article
- The temporal dedifferentiation of global brain signal fluctuations during human brain ageing.Scientific reports · 2022Article
- Low-Rank Tucker-2 Model for Multi-Subject fMRI Data Decomposition With Spatial Sparsity Constraint.IEEE transactions on medical imaging · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Development and aging are associated with functional changes in the brain across the lifespan. These changes manifest in a variety of spatial and temporal features of resting state functional MRI (rs-fMRI) but have seldom been explored exhaustively. We present a comprehensive study assessing age-related changes in spatial and temporal features of blind-source separated components identified by independent vector analysis (IVA) in a cross-sectional lifespan sample (ages 6-85 years). We show that while large-scale network configurations remain consistent throughout the lifespan, changes persist in both local and global organization of these networks. We show that the spatial extent of the majority of functional networks exhibits linear decreases and both positive and negative quadratic trajectories across the lifespan. Network connectivity revealed nuanced patterns of linear and quadratic relationships with age, primarily in higher order cognitive networks. We also show divergent age-related patterns across the frequency spectrum in lower and higher frequencies. Taken together, these results point to the presence of sophisticated patterns of age-related changes that have previously not been considered collectively. We suggest that established patterns of lifespan changes in rs-fMRI features may be driven by changes in the spectral composition of BOLD signals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.