ArticleDevelopmental biology2018
C8orf46 homolog encodes a novel protein Vexin that is required for neurogenesis in Xenopus laevis.
Article in Developmental biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 15 citations in OpenAlex.
- A Role for Astrocyte Metabolism in Species-Specific Neuronal Development.bioRxiv : the preprint server for biology · 2026Article
- Article
- Clinical and Epidemiological Study of Intracranial Tumors in Children and Identification of Diagnostic Biomarkers for the Most Common Tumor Subtype and Their Relationship with the Immune Microenvironment Through Bioinformatics Analysis.Journal of molecular neuroscience : MN · 2022Article
- A single-cell guide to retinal development: Cell fate decisions of multipotent retinal progenitors in scRNA-seq.Developmental biology · 2021Review
- The proteome of granulovacuolar degeneration and neurofibrillary tangles in Alzheimer's disease.Acta neuropathologica · 2021Article
- Atoh7-independent specification of retinal ganglion cell identity.Science advances · 2021Article
- Vexin is upregulated in cerebral cortical neurons by brain-derived neurotrophic factor.Neuropsychopharmacology reports · 2020Article
- Single-Cell Analysis of Human Retina Identifies Evolutionarily Conserved and Species-Specific Mechanisms Controlling Development.Developmental cell · 2020Article
- Xenopus embryos show a compensatory response following perturbation of the Notch signaling pathway.Developmental biology · 2020Article
- Transcriptional profiling of murine retinas undergoing semi-synchronous cone photoreceptor differentiation.Developmental biology · 2019Article
- Monozygotic twins and triplets discordant for amyotrophic lateral sclerosis display differential methylation and gene expression.Scientific reports · 2019Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Neural basic helix-loop helix (bHLH) transcription factors promote progenitor cell differentiation by activation of downstream target genes that coordinate neuronal differentiation. Here we characterize a neural bHLH target gene in Xenopus laevis, vexin (vxn; previously sbt1), that is homologous to human c8orf46 and is conserved across vertebrate species. C8orf46 has been implicated in cancer progression, but its function is unknown. Vxn is transiently expressed in differentiating progenitors in the developing central nervous system (CNS), and is required for neurogenesis in the neural plate and retina. Its function is conserved, since overexpression of either Xenopus or mouse vxn expands primary neurogenesis and promotes early retinal cell differentiation in cooperation with neural bHLH factors. Vxn protein is localized to the cell membrane and the nucleus, but functions in the nucleus to promote neural differentiation. Vxn inhibits cell proliferation, and works with the cyclin-dependent kinase inhibitor p27Xic1 (cdkn1b) to enhance neurogenesis and increase levels of the proneural protein Neurog2. We propose that vxn provides a key link between neural bHLH activity and execution of the neurogenic program.
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