Evidence map›Paper›PMID 29518355›Full record

ReviewNeuron2018

A Systems Neuroscience Approach to Migraine.

K C Brennan, Daniela Pietrobon

Abstract readReview
In one paragraph

Review in Neuron, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 138 papers.

0numbers the graph read from it
0cells of the map it votes in
138citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

138 citing papers in PubMed.

  1. High-definition tDCS over primary motor cortex modulates brain signal variability and functional connectivity in episodic migraine.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024
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  4. Hemiplegic migraine: genetics and pathophysiology.The Journal of clinical investigation · 2026
    Review
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  14. Beyond the headache: autonomic reflex dysfunction and heightened sensory sensitivity contribute to orthostatic intolerance in migraine.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026
    Article
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  18. Review
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78 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

K C BrennanDepartment of Neurology, University of Utah, 383 Colorow Drive, Salt Lake City, UT 84108, USA. Electronic address: k.c.brennan@hsc.utah.edu.
Daniela PietrobonDepartment of Biomedical Sciences and Padova Neuroscience Center, University of Padova, 35131 Padova, Italy; CNR Institute of Neuroscience, Via Ugo Bassi 58/B, 35131 Padova, Italy. Electronic address: daniela.pietrobon@unipd.it.

Funding

Astrocytic mechanisms in a new genetic model of migraineR01NS104742 · NINDS · UNIVERSITY OF UTAH · PI BRENNAN, KEVIN CHRISTOPHER · 2018 to 2022
$2.5M
Noncanonical glutamate signaling in the origins of the migraine attackR37NS102978 · NINDS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Kevin Christopher Brennan · 2024 to 2026
$2.0M
Sensory plasticity in migraineR01NS085413 · NINDS · UNIVERSITY OF UTAH · PI BRENNAN, KEVIN CHRISTOPHER · 2013 to 2017
$1.7M
Cortical Spreading Depression in the Origins of the Migraine AttackR01NS102978 · NINDS · UNIVERSITY OF UTAH · PI BRENNAN, KEVIN CHRISTOPHER · 2017 to 2021
$1.7M
NINDS NIH HHS R01 NS085413NINDS NIH HHS R01 NS102978NINDS NIH HHS R01 NS104742NINDS NIH HHS R37 NS102978Telethon GGP14234
6 · The paper itself

Abstract

Migraine is an extremely common but poorly understood nervous system disorder. We conceptualize migraine as a disorder of sensory network gain and plasticity, and we propose that this framing makes it amenable to the tools of current systems neuroscience.

Indexed as

Systems AnalysisAnimalsBrainCortical Spreading DepressionHumansMigraine DisordersNerve NetNeuronal PlasticityNeurosciencesPsychomotor Performanceallodyniacortical spreading depressiongainmigrainepainphotophobiaplasticitysystems neuroscience

Identifiers

PMID29518355
PMCPMC6402597

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.