Evidence map›Paper›PMID 29518352›Full record

ArticleExperimental eye research2018

Loss of cone function without degeneration in a novel Gnat2 knock-out mouse.

Kaitryn E Ronning, Gabriel Peinado Allina, Eric B Miller, Robert J Zawadzki, Edward N Pugh, Rolf Herrmann, Marie E Burns

Open access · hybridAbstract read
In one paragraph

Article in Experimental eye research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 44 citations in OpenAlex.

  1. Divergence of Melanopsin's Intrinsic Properties and Downstream Actions.bioRxiv : the preprint server for biology · 2026
    Article
  2. E122Q rhodopsin: pigment microspectrophotometry, photoreceptor light responses, and bleaching adaptation.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026
    Article
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  13. Synaptotagmin-9 in mouse retina.Visual neuroscience · 2024
    Article
  14. The Structural and Functional Integrity of Rod Photoreceptor Ribbon Synapses Depends on Redundant Actions of Dynamins 1 and 3.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  15. Review
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  17. SYNAPTOTAGMIN-9 IN MOUSE RETINA.bioRxiv : the preprint server for biology · 2024
    Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Kaitryn E RonningCenter for Neuroscience, University of California Davis, Davis, CA 95616, USA.
Gabriel Peinado AllinaCenter for Neuroscience, University of California Davis, Davis, CA 95616, USA.
Eric B MillerCenter for Neuroscience, University of California Davis, Davis, CA 95616, USA.
Robert J ZawadzkiDepartment of Cell Biology and Human Anatomy, University of California Davis, Davis, CA 95616, USA; EyePod Small Animal Ocular Imaging Laboratory, University of California Davis, Davis, CA 95616, USA; Department of Ophthalmology & Vision Science, University of California Davis, Davis, CA 95616, USA.
Edward N PughDepartment of Cell Biology and Human Anatomy, University of California Davis, Davis, CA 95616, USA; EyePod Small Animal Ocular Imaging Laboratory, University of California Davis, Davis, CA 95616, USA; Department of Ophthalmology & Vision Science, University of California Davis, Davis, CA 95616, USA.
Rolf HerrmannDepartment of Ophthalmology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Marie E BurnsCenter for Neuroscience, University of California Davis, Davis, CA 95616, USA; Department of Cell Biology and Human Anatomy, University of California Davis, Davis, CA 95616, USA; Department of Ophthalmology & Vision Science, University of California Davis, Davis, CA 95616, USA. Electronic address: meburns@ucdavis.edu.
University of California, Davis · USMedical College of Wisconsin · US

Funding

KOMP2-Phase3 Production and Phenotyping by the DTCC Consortium TCP Transfer to UC DavisUM1OD023221 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KC KENT LLOYD · 2016 to 2026
$45.7M
UC Davis MCB T32 Administrative Supplement to Recognize Excellence in Diversity, Equity, Inclusion, and Accessibility (DEIA) MentorshipT32GM007377 · NIGMS · UNIVERSITY OF CALIFORNIA DAVIS · PI CHEDIN, FREDERIC LOUIS · 1985 to 2023
$9.9M
Deactivation Mechanisms of Rod PhototransductionR01EY014047 · NEI · UNIVERSITY OF CALIFORNIA DAVIS · PI BURNS, MARIE E · 2002 to 2020
$8.5M
Vision Science Training Program: Cornea to CortexT32EY015387 · NEI · UNIVERSITY OF CALIFORNIA DAVIS · PI MARIE E BURNS · 2003 to 2026
$4.8M
Theranostics of Photoreceptor-RPE-Choroid Neurovascular Unit in Mouse Models of Eye DiseasesR01EY026556 · NEI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Robert J Zawadzki · 2017 to 2026
$4.1M
NEI NIH HHS R01 EY014047NEI NIH HHS R01 EY026556NEI NIH HHS T32 EY015387NIGMS NIH HHS T32 GM007377NIH HHS UM1 OD023221
6 · The paper itself

Abstract

Rods and cones mediate visual perception over 9 log units of light intensities, with both photoreceptor types contributing to a middle 3-log unit range that comprises most night-time conditions. Rod function in this mesopic range has been difficult to isolate and study in vivo because of the paucity of mutants that abolish cone signaling without causing photoreceptor degeneration. Here we describe a novel Gnat2 knockout mouse line (Gnat2

Indexed as

AnimalsElectroretinographyEye ProteinsGene Knockout TechniquesGenotyping TechniquesHeterotrimeric GTP-Binding ProteinsImmunohistochemistryMiceMice, Inbred C57BLMice, KnockoutReal-Time Polymerase Chain ReactionRetinal Cone Photoreceptor CellsRetinal DegenerationRetinal Rod Photoreceptor CellsTomography, Optical CoherenceVision, OcularEye ProteinsGnat2 protein, mouseHeterotrimeric GTP-Binding ProteinsG-proteinPhotoreceptorPhototransductionRetina

Identifiers

PMID29518352
PMCPMC5987249
OpenAlexW2792651599

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.