Evidence map›Paper›PMID 29518187›Full record

ArticleBiology of reproduction2018

Potent and rapid activation of tropomyosin-receptor kinase A in endometrial stromal fibroblasts by seminal plasma.

Jeremy W Martin, Joseph C Chen, Jason Neidleman, Keiji Tatsumi, James Hu, Linda C Giudice, Warner C Greene, Nadia R Roan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology of reproduction, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Jeremy W MartinDepartment of Urology, UCSF, San Francisco, California, USA.
Joseph C ChenDepartment of Obstetrics, Gynecology and Reproductive Sciences, UCSF, San Francisco, California, USA.
Jason NeidlemanDepartment of Urology, UCSF, San Francisco, California, USA.
Keiji TatsumiDepartment of Obstetrics, Gynecology and Reproductive Sciences, UCSF, San Francisco, California, USA.
James HuGladstone Institute of Virology and Immunology, UCSF, San Francisco, California, USA.
Linda C GiudiceDepartment of Obstetrics, Gynecology and Reproductive Sciences, UCSF, San Francisco, California, USA.
Warner C GreeneGladstone Institute of Virology and Immunology, UCSF, San Francisco, California, USA.
Nadia R RoanDepartment of Urology, UCSF, San Francisco, California, USA.
Gladstone Institutes · USUniversity of California, San Francisco · USOsaka National Hospital · JP

Funding

Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS · 1988 to 2026
$93.6M
Project 4: Human Endometrial Programming for Successful ImplantationP50HD055764 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GIUDICE, LINDA C · 2014 to 2022
$16.4M
Viral and Host Factors Promoting Male-to-Female Transmission of HIVP01AI083050 · NIAID · J. DAVID GLADSTONE INSTITUTES · PI GREENE, WARNER C. · 2009 to 2013
$10.1M
Elucidating the mechanism of progesterone-induced permissivity in the upperfemale reproductive tractR01AI127219 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROAN, NADIA R · 2016 to 2020
$2.1M
Characterization of Exosomes From Semen of Uninfected and HIV-Infected MenR21AI122821 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROAN, NADIA R · 2016 to 2017
$450k
Characterization of Gallic Acid as a Novel HIV Microbicide CandidateR21AI116252 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROAN, NADIA R · 2015 to 2016
$436k
NIAID NIH HHS P01 AI083050NIAID NIH HHS P30 AI027763NIAID NIH HHS R01 AI127219NIAID NIH HHS R21 AI116252NIAID NIH HHS R21 AI122821NICHD NIH HHS P50 HD055764
6 · The paper itself

Abstract

Seminal plasma (SP), the liquid fraction of semen, is not mandatory for conception, but clinical studies suggest that SP improves implantation rates. Prior in vitro studies examining the effects of SP on the endometrium, the site of implantation, surprisingly revealed that SP induces transcriptional profiles associated with neurogenesis. We investigated the presence and activity of neurogenesis pathways in the endometrium, focusing on TrkA, one of the canonical receptors associated with neurotrophic signaling. We demonstrate that TrkA is expressed in the endometrium. To determine if SP activates TrkA signaling, we isolated the two most abundant endometrial cell types-endometrial epithelial cells (eEC) and endometrial stromal fibroblasts (eSF)-and examined TrkA activity in these cells after SP exposure. While SP only moderately activated TrkA in eEC, it potently and rapidly activated TrkA in eSF. This activation occurred in both non-decidualized and decidualized eSF. Blocking this pathway resulted in dysregulation of SP-induced cytokine production by eSF. Surprisingly, while the canonical TrkA agonist nerve growth factor was detected in SP, TrkA activation was principally induced by a 30-100-kDa protein whose identity remains to be established. Our results show that TrkA signaling is highly active in eSF and is rapidly induced by SP.

Indexed as

AdultEmbryo ImplantationEndometriumFemaleFibroblastsHumansPhosphorylationReceptor, trkASemenSignal TransductionStromal CellsNTRK1 protein, humanReceptor, trkA

Identifiers

PMID29518187
PMCPMC6084595
OpenAlexW2790978973

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.