ArticleMolecules (Basel, Switzerland)2018
Anthocyanin-Rich Grape Pomace Extract (Vitis vinifera L.) from Wine Industry Affects Mitochondrial Bioenergetics and Glucose Metabolism in Human Hepatocarcinoma HepG2 Cells.
Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 47 citations in OpenAlex.
- Dietary grape pomace mitigates high-NSP-induced inflammation and production loss via microbiome-SCFA-immune mediated pathways.NPJ biofilms and microbiomes · 2026Article
- A Preliminary Analysis of the Influence of Elderberry Juice Consumption on Thyroid Metabolism in Mice and Humans Fed High-Fat Diets.Nutrients · 2025Article
- Mixed Berry Juice and Cellulose Fiber Have Differential Effects on Peripheral Blood Mononuclear Cell Respiration in Overweight Adults.Nutrients · 2023Article
- Pulsed electric fields-assisted extraction of valuable compounds from red grape pomace: Process optimization using response surface methodology.Frontiers in nutrition · 2023Article
- Review
- Effects of Grape Pomace Polyphenols and In Vitro Gastrointestinal Digestion on Antimicrobial Activity: Recovery of Bioactive Compounds.Antioxidants (Basel, Switzerland) · 2022Article
- In Vitro Evaluation of Biological Activities of Canes and Pomace Extracts from Several Varieties ofAntioxidants (Basel, Switzerland) · 2022Article
- Sweet Cherries as Anti-Cancer Agents: From Bioactive Compounds to Function.Molecules (Basel, Switzerland) · 2021Review
- The Potential of Selected Agri-Food Loss and Waste to Contribute to a Circular Economy: Applications in the Food, Cosmetic and Pharmaceutical Industries.Molecules (Basel, Switzerland) · 2021Review
- Microencapsulation of Red Grape Juice by Freeze Drying and Application in Jelly Formulation.Food technology and biotechnology · 2020Article
- Antioxidant, Anti-Inflammatory and Antiproliferative Effects of theFrontiers in pharmacology · 2020Article
- Special Issue: The Antioxidant Capacities of Natural Products.Molecules (Basel, Switzerland) · 2019Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancer cells demand high ATP provisions to support proliferation, and targeting of energy metabolism is a good strategy to increase their sensitivity to treatments. In Brazil, wine manufacture is expanding, increasing the amount of pomace that is produced. We determined the phenolic composition and antioxidant properties of a dark skin Grape Pomace Extract and its effects on metabolism and redox state in human hepatocarcinoma HepG2 cells. The material and the methods used represented the industrial process since pomace derived from white wine production and the extract concentrated by pilot plant scale reverse osmosis. Grape pomace extract was rich in polyphenols, mainly anthocyanins, and presented high antioxidant capacity. Short-term metabolic effects, irrespective of any cytotoxicity, involved increased mitochondrial respiration and antioxidant capacity and decreased glycolytic metabolism. Long-term incubation was cytotoxic and cells died by necrosis and GPE was not toxic to non-cancer human fibroblasts. To the best of our knowledge, this is the first report to characterize pomace extract from white wine production from Brazilian winemaking regarding its effects on energy metabolism, suggesting its potential use for pharmaceutical and nutraceutical purposes.
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