SynthesisBlood transfusion = Trasfusione del sangue2018
The use of viscoelastic haemostatic assays in non-cardiac surgical settings: a systematic review and meta-analysis.
Synthesis in Blood transfusion = Trasfusione del sangue, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The use of platelet-rich plasma in oral surgery: a systematic review and meta-analysis.Blood transfusion = Trasfusione del sangue · 2019Pooled it
- Thromboelastography-guided therapy improves patient blood management and certain clinical outcomes in elective cardiac and liver surgery and emergency resuscitation: A systematic review and analysis.Journal of thrombosis and haemostasis : JTH · 2019Pooled it
- Challenges and opportunities in ECMO monitoring: A mixed-methods appraisal.The journal of extra-corporeal technology · 2026Review
- Revisiting the Concept of DIC: A Phenotype-guided Framework for Modern Hemostatic Medicine.Juntendo medical journal · 2026Review
- Healthcare professionals' knowledge, attitudes and practices in thromboelastography application.Frontiers in medicine · 2025Article
- Fibrinogen contribution to clot strength in patients with sepsis and hematologic malignancies and thrombocytopenia-a prospective, single-center, analytical, cross-sectional study.Research and practice in thrombosis and haemostasis · 2024Article
- Protease-activated receptors and glycoprotein VI cooperatively drive the platelet component in thromboelastography.Journal of thrombosis and haemostasis : JTH · 2023Article
- Response to comment on "A rare case of Wilson disease associated with intracerebral hemorrhage".Korean journal of anesthesiology · 2021Article
- "TEG talk": expanding clinical roles for thromboelastography and rotational thromboelastometry.Hematology. American Society of Hematology. Education Program · 2020Article
- Dynamic functional clot formation in patients undergoing endoscopic mucosal resection.JGH open : an open access journal of gastroenterology and hepatology · 2020Article
- Patient Blood Management: a revolutionary approach to transfusion medicine.Blood transfusion = Trasfusione del sangue · 2019Review
- Influence of Fractionation Methods on Physical and Biological Properties of Injectable Platelet-Rich Fibrin: An Exploratory Study.International journal of molecular sciences · 2019Article
- Tranexamic acid to prevent post-partum haemorrhage.Blood transfusion = Trasfusione del sangue · 2018Article
- The use of viscoelastic haemostatic assays in non-cardiac surgical settings: a systematic review and meta-analysis.Blood transfusion = Trasfusione del sangue · 2018Article
- A Survey on the implementation of Patient Blood Management programs in Italy.Blood transfusion = Trasfusione del sangueArticle
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThrombelastography (TEG) and rotational thromboelastometry (ROTEM) are viscoelastic haemostatic assays (VHA) which exploit the elastic properties of clotting blood. The aim of this systematic review and meta-analysis was to evaluate the usefulness of these tests in bleeding patients outside the cardiac surgical setting. MATERIALS AND
methodsWe searched the Cochrane Library, MEDLINE, EMBASE and SCOPUS. We also searched clinical trial registries for ongoing and unpublished studies, and checked reference lists to identify additional studies.
resultsWe found 4 randomised controlled trials (RCTs) that met our inclusion criteria with a total of 229 participants. The sample size was small (from 28 to 111 patients) and the follow-up periods very heterogenous (from 4 weeks to 3 years). Pooled data from the 3 trials reporting on mortality (199 participants) do not show any effect of the use of TEG on mortality as compared to standard monitoring (based on the average treatment effect from a fixed-effects model): Risk Ratio (RR) 0.71; 95% Confidence Interval (CI): 0.43 to 1.16. Likewise, the use of VHA does not reduce the need for red blood cells (mean difference -0.64; 95% CI: -1.51 to 0.23), platelet concentrates (mean difference -1.12; 95% CI: -3.25 to 1.02), and fresh frozen plasma (mean difference -0.91; 95% CI: -2.02 to 0.19) transfusion. The evidence on mortality and other outcomes was uncertain (very low-certainty evidence, down-graded due to risk of biases, imprecision, and inconsistency).
conclusionsOverall, the certainty of the evidence provided by the trials was too low for us to be certain of the benefits and harms of viscoelastic haemostatic assay in non-cardiac surgical settings. More, larger, and better-designed RCTs should be carried out in this area.
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