ArticleAging cell2018
Properties of the vastus lateralis muscle in relation to age and physiological function in master cyclists aged 55-79 years.
Article in Aging cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Sex differences in human skeletal muscle fiber types and the influence of age, physical activity, and muscle group: A systematic review and meta-analysis.Physiological reports · 2025Pooled it
- The role of exercise induced capillarization adaptations in skeletal muscle aging: a systematic review.Frontiers in physiology · 2025Pooled it
- The use of tensiomyography in older adults: a systematic review.Frontiers in physiology · 2023Pooled it
- mTORC1 signalling and protein synthesis are elevated in response to amino acids in human myotubes obtained from young, old, and old trained men.In vitro cellular & developmental biology. Animal · 2026Article
- Leg and hip muscles show muscle-specific effects of ageing and sport on muscle volume and fat fraction in male Masters athletes.The Journal of physiology · 2026Article
- A randomized controlled trial effect of forest hiking on tensor muscle function, erythrocyte factors, and leukocytes' subsets in older adults: a pilot study.Journal of exercise rehabilitation · 2025Article
- Myonuclear alterations associated with exercise are independent of age in humans.The Journal of physiology · 2025Article
- A 10-Year Longitudinal Study of Muscle Morphology and Performance in Masters Sprinters.Journal of cachexia, sarcopenia and muscle · 2025Article
- The skeletal muscle proteomic determinants of neuromuscular function in young and older women following 8 weeks of resistance training.Experimental physiology · 2025Article
- Muscle fibre size and myonuclear positioning in trained and aged humans.Experimental physiology · 2024Article
- No ageing-related increase in fibre type grouping in sprint-trained masters runners: A 10-year follow-up study.Journal of cachexia, sarcopenia and muscle · 2024Article
- Fast and slow muscle fiber transcriptome dynamics with lifelong endurance exercise.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- A physiological comparison of the new-over 70 years of age-marathon record holder and his predecessor: A case report.Frontiers in physiology · 2023Article
- Age-Related Study of Anthropometry Indicators, Body Composition, Strength and Vital Capacity at Masters Athletics: How to Postpone Sarcopenia.Clinical interventions in aging · 2023Article
- No effect of five days of bed rest or short-term resistance exercise prehabilitation on markers of skeletal muscle mitochondrial content and dynamics in older adults.Physiological reports · 2022Article
- Acute resistance exercise training does not augment mitochondrial remodelling in master athletes or untrained older adults.Frontiers in physiology · 2022Article
- Association between age and muscle function, architecture, and composition in long-distance master runners: a cross-sectional study.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2022Article
- Endurance training-induced increase in muscle oxidative capacity without loss of muscle mass in younger and older resistance-trained men.European journal of applied physiology · 2021Article
- Article
- The Effects of Lifestyle and Diet on Gut Microbiota Composition, Inflammation and Muscle Performance in Our Aging Society.Nutrients · 2021Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
In this study, results are reported from the analyses of vastus lateralis muscle biopsy samples obtained from a subset (n = 90) of 125 previously phenotyped, highly active male and female cyclists aged 55-79 years in regard to age. We then subsequently attempted to uncover associations between the findings in muscle and in vivo physiological functions. Muscle fibre type and composition (ATPase histochemistry), size (morphometry), capillary density (immunohistochemistry) and mitochondrial protein content (Western blot) in relation to age were determined in the biopsy specimens. Aside from an age-related change in capillary density in males (r = -.299; p = .02), no other parameter measured in the muscle samples showed an association with age. However, in males type I fibres and capillarity (p < .05) were significantly associated with training volume, maximal oxygen uptake, oxygen uptake kinetics and ventilatory threshold. In females, the only association observed was between capillarity and training volume (p < .05). In males, both type II fibre proportion and area (p < .05) were associated with peak power during sprint cycling and with maximal rate of torque development during a maximal voluntary isometric contraction. Mitochondrial protein content was not associated with any cardiorespiratory parameter in either males or females (p > .05). We conclude in this highly active cohort, selected to mitigate most of the effects of inactivity, that there is little evidence of age-related changes in the properties of VL muscle across the age range studied. By contrast, some of these muscle characteristics were correlated with in vivo physiological indices.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.