SynthesisMedicine2018
The efficacy and safety of nefopam for pain relief during laparoscopic cholecystectomy: A meta-analysis.
Synthesis in Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- The safety and efficacy of peri-operative nefopam for analgesia in hip and knee arthroplasty: A systematic review and meta-analysis.European journal of clinical pharmacology · 2026Pooled it
- Trial
- The Analgesic Effect of Nefopam in Patients Undergoing Orthopedics Surgery with Tourniquet: a Double-blind Case-control Trial.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2025Trial
- Comparison of analgesic effectiveness between nefopam and propacetamol in living kidney donors following rectus sheath block after hand-assisted living donor nephrectomy: a prospective, randomized controlled trial.BMC anesthesiology · 2024Trial
- Impact of Intraoperative Nefopam on Postoperative Pain, Opioid Use, and Recovery Quality with Parietal Pain Block in Single-Port Robotic Cholecystectomy: A Prospective Randomized Controlled Trial.Medicina (Kaunas, Lithuania) · 2024Trial
- Effect of Ultrasound-Guided Transversus Abdominis Plane Block Combined with Patient-Controlled Intravenous Analgesia on Postoperative Analgesia After Laparoscopic Cholecystectomy: a Double-Blind, Randomized Controlled Trial.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2022Trial
- Effect of Nefopam-Based Patient-Controlled Analgesia with and without Fentanyl on Postoperative Pain Intensity in Patients Following Laparoscopic Cholecystectomy: A Prospective, Randomized, Controlled, Double-Blind Non-Inferiority Trial.Medicina (Kaunas, Lithuania) · 2021Trial
- Effects of Nefopam on Postoperative Analgesia in Operating Room-Extubated Patients Undergoing Living Donor Liver Transplantation: A Propensity Score-Matched Analysis.Life (Basel, Switzerland) · 2025Article
- Effect of Intraoperative Nefopam on Postoperative Analgesia in Living Liver Donors Undergoing Laparoscopic Hepatectomy with Transversus Abdominis Plane Block: A Propensity Score-Matched Study.Life (Basel, Switzerland) · 2025Article
- A meta analysis of efficacy and safety of nefopam for laparoscopic cholecystectomy pain management.Journal of Taibah University Medical Sciences · 2025Article
- Efficacy of Intraoperative Paracetamol and Nefopam Infusions in Addition to Transversus Abdominis Plane Block in Kidney Transplant Recipients.Medicina (Kaunas, Lithuania) · 2025Article
- Analgesic effect of intravenous nefopam for postoperative pain in spine surgery: a meta-analysis of RCTs.International journal of physiology, pathophysiology and pharmacology · 2025Review
- Nefopam as a multimodal analgesia in thoracoscopic surgery: a randomized controlled trial.Journal of thoracic disease · 2024Article
- The Lack of Analgesic Efficacy of Nefopam after Video-Assisted Thoracoscopic Surgery for Lung Cancer: A Randomized, Single-Blinded, Controlled Trial.Journal of clinical medicine · 2022Article
- Perioperative Intravenous Patient-Controlled Analgesic Efficacy of Morphine with Combined Nefopam and Parecoxib versus Parecoxib in Gynecologic Surgery: A Randomized, Double-Blind Study.Anesthesiology research and practice · 2021Review
- The Antiallodynic Effect of Nefopam on Vincristine-Induced Neuropathy in Mice.Journal of pain research · 2020Article
- Pharmacologic targeting of β-catenin improves fracture healing in old mice.Scientific reports · 2019Article
- Comparison of the sonographic findings in laparoscopic cholecystostomy with and without hemostatic agent on 45-day follow-up of patients attending hospital.Journal of family medicine and primary care · 2019Article
- Intravenous lidocaine bolus for reducing nefopam-induced venous pain: A randomized, intrasubject comparison trial.Journal of anaesthesiology, clinical pharmacologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPain control after laparoscopic cholecystectomy (LC) has become an important topic. We performed a meta-analysis of randomized controlled trials (RCTs) to evaluate the efficacy and safety of nefopam for pain management after LC.
methodsPubMed, Medline, Embase, ScienceDirect, and the Cochrane Library were searched up to November 2017 for comparative articles involving nefopam and placebo for reducing postoperative pain after LC. Primary outcomes were postoperative pain scores and opioid consumption. Secondary outcomes were length of hospital stay, opioid-related adverse effects, and postoperative complications. We assessed statistical heterogeneity for each RCT by using a standard Chi test and the I statistic. The meta-analysis was undertaken using Stata 12.0.
resultsA total of 215 patients were analyzed across 4 RCTs. We found that there were significant differences between nefopam and placebo groups regarding the postoperative pain scores and opioid requirements at 6, 12, and 24 hours. Moreover, there was a decreased risk of opioid-related adverse effects in the nefopam groups. No significant differences were identified in terms of the incidence of postoperative complications.
conclusionIntravenous nefopam infusion resulted in significant reduction in postoperative pain scores and opioid requirements while decreasing opioid-related adverse effects. Additionally, no increased risk of venous thromboembolism was found. The current evidence suggests that more RCTs will be needed in further investigations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.