Observational studyInternational forum of allergy & rhinology2018
Preoperative Lund-Mackay computed tomography score is associated with preoperative symptom severity and predicts quality-of-life outcome trajectories after sinus surgery.
Observational study in International forum of allergy & rhinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Sinonasal Inflammatory Burden on Computed Tomography in Adults With Obstructive Eustachian Tube Dysfunction: A Case-Control Study.Laryngoscope investigative otolaryngology · 2026Article
- Unsupervised radiomics-driven endotyping of chronic rhinosinusitis with nasal polyps: a multimodal characterization of CT imaging, clinical phenotypes, and proteomic profiling.BMC medical imaging · 2026Article
- Association Between Subjective Symptom Severity and Radiologic Involvement in CRSwNP Patients Using SNOT-22 and Lund-Mackay Scores.Iranian journal of otorhinolaryngology · 2026Article
- The use of a convolutional neural network to automate radiologic scoring of computed tomography of paranasal sinuses.Biomedical engineering online · 2025Article
- Sino-Nasal Outcome Test-22: translation, cross-cultural adaptation, and validation in Polish-speaking patients.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Article
- Role of Functional Endoscopic Sinus Surgery in Patients with Chronic Rhinosinusitis and Laryngopharyngeal Reflux: A Prospective Study.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024Article
- Review
- Sino-nasal outcome Test-22 and Lund-Mackay CT score to select endoscopic sinus surgery in chronic rhinosinusitis.World journal of otorhinolaryngology - head and neck surgery · 2024Article
- Outcomes of endoscopic sinus surgery in patients with central compartment atopic disease.The World Allergy Organization journal · 2024Article
- Development and validation of a nomogram for predicting poor operative visibility during FESS in Chinese adult patients with CRS.Frontiers in medicine · 2024Article
- Gαi1/3 signaling mediates IL-5-induced eosinophil activation and type 2 inflammation in eosinophilic chronic rhinosinusitis.Frontiers in immunology · 2024Article
- CXCR5Frontiers in immunology · 2024Article
- Worsening Rhinosinusitis as a Prognostic Factor for Patients with Nasopharyngeal Carcinoma: A Retrospective Study.Biomedicines · 2022Article
- Modified CT Scan Scoring System for Evaluating Symptom Severity of Chronic Rhinosinusitis.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022Article
- When rhinosinusitis is not just rhinosinusitis: Clinical characteristics and phenotypes of patients with type 2 chronic rhinosinusitis with nasal polyps.Acta bio-medica : Atenei Parmensis · 2022Article
- Bacterial community of chronic rhinosinusitis patients and therapeutic ultrasound efficacy: clinical trial study.Iranian journal of microbiology · 2022Article
- Semi-Supervised Deep Learning Semantic Segmentation for 3D Volumetric Computed Tomographic Scoring of Chronic Rhinosinusitis: Clinical Correlations and Comparison with Lund-Mackay Scoring.Tomography (Ann Arbor, Mich.) · 2022Article
- Preoperative Sinonasal Computed Tomography Score in Chronic Rhinosinusitis with Nasal Polyps.Tomography (Ann Arbor, Mich.) · 2022Article
- Validation and Clinical Application of the Turkish Version of the RhinoQOL Questionnaire in the Setting of Chronic Rhinosinusitis with Nasal Polyp Patients.Sisli Etfal Hastanesi tip bulteni · 2022Article
- Molecular Imaging of Inflammatory Disease.Biomedicines · 2021Review
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11 authors.
Funding
Abstract
backgroundDisagreement exists about the relationship between Lund-Mackay CT scores (LMCTS) and quality-of-life outcome (QoL) measures. We investigated whether preoperative LMCTS are associated with preoperative QoL, and whether LMCTS is predictive of postoperative QoL outcomes in chronic rhinosinusitis (CRS) patients.
methodsAdult patients with medically recalcitrant CRS (n = 665) were enrolled in a prospective, observational cohort study. Preoperative LMCTS and pre- and postoperative self-reported QoL outcomes (22-item Sino-Nasal Outcomes Test [SNOT-22]) were collected and evaluated over 12 months. Five hundred sixty-eight patients met the inclusion criteria. Longitudinal linear mixed-effects modeling was used to investigate the effect of LMCTS on QoL after functional endoscopic sinus surgery (FESS).
resultsPreoperative LMCTS were significantly associated with preoperative SNOT-22 scores (p < 0.01) and postoperative SNOT-22 scores (p < 0.001), driven by Extranasal and Rhinologic subdomains of the QoL questionaire. Patients in the lowest preoperative LMCTS quartile had the lowest mean change in SNOT-22 scores at 12 months (16.8 points; 95% confidence interval [CI], 12.2-21.3). Patients in the second and third lowest preoperative LMCTS quartiles had mean changes at 12 months of 21.1 points (95% CI, 16.7-25.4) and 23.1 points (95% CI, 18.3-27.9). Patients in the highest preoperative LMCTS quartile had the greatest improvement in SNOT-22 scores after FESS (29.9 points; 95% CI, 24.9-34.8). The difference in QoL change at 12 months between the highest and lowest preoperative LMCTS quartiles was 13.1 points (95% CI, 6.0-20.2; p < 0.001).
conclusionOur study demonstrates that preoperative LMCTS correlate with preoperative extranasal and rhinologic symptom severity and that the LMCTS is an indicator of postsurgical QoL outcomes for medically recalcitrant chronic rhinosinusitis patients in a large tertiary otolaryngology setting.
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