ArticleAmerican journal of physiology. Lung cellular and molecular physiology2018
Time-resolved proteome profiling of normal lung development.
Article in American journal of physiology. Lung cellular and molecular physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 32 citations in OpenAlex.
- A deep generative model for deciphering cellular dynamics and in silico drug discovery in complex diseases.Nature biomedical engineering · 2025Article
- Multi-omics of a model bacterial consortium deciphers details of chitin decomposition in soil.mBio · 2025Article
- Cell Population-resolved Multiomics Atlas of the Developing Lung.American journal of respiratory cell and molecular biology · 2025Article
- The mouse multi-organ proteome from infancy to adulthood.Nature communications · 2024Article
- Molecular distinctions of bronchoalveolar and alveolar organoids under differentiation conditions.Physiological reports · 2024Article
- LungMAP Portal Ecosystem: Systems-level Exploration of the Lung.American journal of respiratory cell and molecular biology · 2024Article
- Chymotrypsin-like Elastase-1 Mediates Progressive Emphysema in Alpha-1 Antitrypsin Deficiency.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2023Article
- Regionally distinct progenitor cells in the lower airway give rise to neuroendocrine and multiciliated cells in the developing human lung.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Influence of the irradiated pulmonary microenvironment on macrophage and T cell dynamics.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2023Article
- Time-resolved transcriptomic profiling of the developing rabbit's lungs: impact of premature birth and implications for modelling bronchopulmonary dysplasia.Respiratory research · 2023Article
- CELA1 Mediates Progressive Emphysema in Alpha-1 Antitrypsin Deficiency.Research square · 2023Article
- A microphysiological model of human trophoblast invasion during implantation.Nature communications · 2022Article
- Proteomic Analysis of Human Lung Development.American journal of respiratory and critical care medicine · 2022Article
- An optimized approach and inflation media for obtaining complimentary mass spectrometry-based omics data from human lung tissue.Frontiers in molecular biosciences · 2022Article
- Single-cell transcriptomics reveals lasting changes in the lung cellular landscape into adulthood after neonatal hyperoxic exposure.Redox biology · 2021Article
- Repetitive diacetyl vapor exposure promotes ubiquitin proteasome stress and precedes bronchiolitis obliterans pathology.Archives of toxicology · 2021Article
- A shift from glycolytic and fatty acid derivatives toward one-carbon metabolites in the developing lung during transitions of the early postnatal period.American journal of physiology. Lung cellular and molecular physiology · 2021Article
- Glucocorticoid regulates mesenchymal cell differentiation required for perinatal lung morphogenesis and function.American journal of physiology. Lung cellular and molecular physiology · 2020Article
- Comprehensive anatomic ontologies for lung development: A comparison of alveolar formation and maturation within mouse and human lung.Journal of biomedical semantics · 2019Article
- High-Throughput Single Cell Proteomics Enabled by Multiplex Isobaric Labeling in a Nanodroplet Sample Preparation Platform.Analytical chemistry · 2019Article
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
Abstract
Biochemical networks mediating normal lung morphogenesis and function have important implications for ameliorating morbidity and mortality in premature infants. Although several transcript-level studies have examined normal lung development, corresponding protein-level analyses are lacking. Here we performed proteomics analysis of murine lungs from embryonic to early adult ages to identify the molecular networks mediating normal lung development. We identified 8,932 proteins, providing a deep and comprehensive view of the lung proteome. Analysis of the proteomics data revealed discrete modules and the underlying regulatory and signaling network modulating their expression during development. Our data support the cell proliferation that characterizes early lung development and highlight responses of the lung to exposure to a nonsterile oxygen-rich ambient environment and the important role of lipid (surfactant) metabolism in lung development. Comparison of dynamic regulation of proteomic and recent transcriptomic analyses identified biological processes under posttranscriptional control. Our study provides a unique proteomic resource for understanding normal lung formation and function and can be freely accessed at Lungmap.net.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.