ArticleJournal of cellular and molecular medicine2018
A novel peptide Phylloseptin-PBu from Phyllomedusa burmeisteri possesses insulinotropic activity via potassium channel and GLP-1 receptor signalling.
Article in Journal of cellular and molecular medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 5 citations in OpenAlex.
- The Amazonian kambô frogFrontiers in pharmacology · 2022Review
- Novel peptide dermaseptin-PS1 exhibits anticancer activity via induction of intrinsic apoptosis signalling.Journal of cellular and molecular medicine · 2019Article
- A novel peptide Phylloseptin-PBu from Phyllomedusa burmeisteri possesses insulinotropic activity via potassium channel and GLP-1 receptor signalling.Journal of cellular and molecular medicine · 2018Article
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5 authors at 1 institution in 1 country.
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Abstract
Insulin, as one of the most important hormones regulating energy metabolism, plays an essential role in maintaining glucose and lipid homeostasis in vivo. Failure or insufficiency of insulin secretion from pancreatic beta-cells increases glucose and free fatty acid level in circulation and subsequently contributes to the emergence of hyperglycaemia and dyslipidaemia. Therefore, stimulating the insulin release benefits the treatment of type 2 diabetes and obesity significantly. Frog skin peptides have been extensively studied for their biological functions, among which, Phylloseptin peptides discovered in Phyllomedusinae frogs have been found to exert antimicrobial, antiproliferative and insulinotropic activities, while the mechanism associated with Phylloseptin-induced insulin secretion remains elusive. In this study, we reported a novel peptide named Phylloseptin-PBu, isolated and identified from Phyllomedusa burmeisteri, exhibited dose-dependent insulinotropic property in rat pancreatic beta BRIN-BD11 cells without altering cell membrane integrity. Further mechanism investigations revealed that Phylloseptin-PBu-induced insulin output is predominantly modulated by K
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