Evidence map›Paper›PMID 29516390›Full record

ArticleAnnals of nuclear medicine2018

Artificial neural network retrained to detect myocardial ischemia using a Japanese multicenter database.

Kenichi Nakajima, Koichi Okuda, Satoru Watanabe, Shinro Matsuo, Seigo Kinuya, Karin Toth, Lars Edenbrandt

Abstract readMulticenter StudyValidation Study
In one paragraph

Article in Annals of nuclear medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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  12. Image-Based Cardiac Diagnosis With Machine Learning: A Review.Frontiers in cardiovascular medicine · 2020
    Review
  13. Review
  14. Artificial intelligence in cardiovascular imaging: state of the art and implications for the imaging cardiologist.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2019
    Review
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kenichi NakajimaDepartment of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, 920-8641, Japan. nakajima@med.kanazawa-u.ac.jp.ORCID http://orcid.org/0000-0001-7188-8746
Koichi OkudaDepartment of Physics, Kanazawa Medical University, Uchinada, Kahoku, Japan.
Satoru WatanabeDepartment of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, 920-8641, Japan.
Shinro MatsuoDepartment of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, 920-8641, Japan.
Seigo KinuyaDepartment of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, 920-8641, Japan.
Karin TothEXINI Diagnostics, Lund, Sweden.
Lars EdenbrandtDepartment of Clinical Physiology and Nuclear Medicine, University of Gothenburg, Gothenburg, Sweden.

Funding

JSPS Grants-in-Aid for Scientific Research (C) 15 K09947(partly) FUJIFILM RI Pharma Co. Ltd. none
6 · The paper itself

Abstract

purposeAn artificial neural network (ANN) has been applied to detect myocardial perfusion defects and ischemia. The present study compares the diagnostic accuracy of a more recent ANN version (1.1) with the initial version 1.0.

methodsWe examined 106 patients (age, 77 ± 10 years) with coronary angiographic findings, comprising multi-vessel disease (≥ 50% stenosis) (52%) or old myocardial infarction (27%), or who had undergone coronary revascularization (30%). The ANN versions 1.0 and 1.1 were trained in Sweden (n = 1051) and Japan (n = 1001), respectively, using

resultsAlthough the AUC for stress defects was 0.95 and 0.93 (p = 0.27) for versions 1.1 and 1.0, respectively, that for detecting ischemia was significantly improved in version 1.1 (p = 0.0055): AUC 0.96 for version 1.1 (sensitivity 87%, specificity 96%) vs. 0.89 for version 1.0 (sensitivity 78%, specificity 97%). The improvement in the AUC shown by version 1.1 was also significant for patients with neither coronary revascularization nor old myocardial infarction (p = 0.0093): AUC = 0.98 for version 1.1 (sensitivity 88%, specificity 100%) and 0.88 for version 1.0 (sensitivity 76%, specificity 100%). Intermediate ANN probability between 0.1 and 0.7 was more often calculated by version 1.1 compared with version 1.0, which contributed to the improved diagnostic accuracy. The diagnostic accuracy of the new version was also improved in patients with either single-vessel disease or no stenosis (n = 47; AUC, 0.81 vs. 0.66 vs. p = 0.0060) when coronary stenosis was used as a gold standard.

conclusionThe diagnostic ability of the ANN version 1.1 was improved by retraining using the Japanese database, particularly for identifying ischemia.

Indexed as

Coronary AngiographyMyocardial Perfusion ImagingNeural Networks, ComputerAgedArea Under CurveArtificial IntelligenceCardiac Surgical ProceduresDatabases as TopicEndovascular ProceduresFemaleHeartHumansImage Interpretation, Computer-AssistedJapanMaleMyocardial IschemiaOrganotechnetium CompoundsRadiopharmaceuticalstechnetium 99m methoxyisobutylisonitrileArtificial intelligenceCoronary artery diseaseMyocardial perfusion imagingNuclear cardiology

Identifiers

PMID29516390
PMCPMC5970255

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.