Evidence map›Paper›PMID 29516271›Full record

ArticleNanoscale research letters2018

Antibody-Conjugated Silica-Modified Gold Nanorods for the Diagnosis and Photo-Thermal Therapy of Cryptococcus neoformans: an Experiment In Vitro.

Qin Xiao, Yongzhou Lu, Min Chen, Bo Chen, Yuming Yang, Daxiang Cui, Bo Pan, Nan Xu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanoscale research letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Qin XiaoDepartment of Dermatology, Shanghai East Hospital, Tongji University, Shanghai, China.
Yongzhou LuDepartment of Dermatology, Shanghai East Hospital, Tongji University, Shanghai, China.
Min ChenDepartment of Dermatology, Changzheng Hospital, Second Military Medical University, Shanghai, China.
Bo ChenDepartment of Radiology, Shanghai East Hospital, Tongji University, Shanghai, China.
Yuming YangInstitute of Nano Biomedicine and Engineering, Shanghai Jiao Tong University, Shanghai, China.
Daxiang CuiInstitute of Nano Biomedicine and Engineering, Shanghai Jiao Tong University, Shanghai, China.
Bo PanDepartment of Dermatology, Changzheng Hospital, Second Military Medical University, Shanghai, China.
Nan XuDepartment of Dermatology, Shanghai East Hospital, Tongji University, Shanghai, China. drluther@163.com.
Shanghai East Hospital · CNSecond Military Medical University · CNShanghai Jiao Tong University · CN

Funding

the National Natural Science Foundation of China 81201234the Shanghai Municipal Commission of Health and Family Planning Scientific Fund 2012134
6 · The paper itself

Abstract

backgroundCryptococcus neoformans is an encapsulated yeast. There is still little quick and effective solution for the diagnosis or treatment of C. neoformans infection at an early stage in clinical. Antibody-conjugated silica-modified gold nanorods (GNR-SiO

methodsGold nanorods (GNRs) were synthesized according to the seed-mediated template-assisted protocol. Anti-C. neoformans antibody was covalently anchored on the surface of GNRs with silane coupling agent. In vitro computer tomography imaging was performed to explore the diagnostic effect of the GNR-SiO

resultsGNR-SiO

conclusionsOur work confirmed that antibody-conjugated silica-modified gold nanorods could enhance X-ray attenuation of C. neoformans cells in CT images. And immune GNRs, which were mediated by antibodies, could increase the effects of NIR-induced photo-thermal therapy in C. neoformans cells.

Indexed as

Cryptococcus neoformansDiagnosisGold nanorodsPhoto-thermal therapy

Identifiers

PMID29516271
PMCPMC5842168
OpenAlexW2795790932

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.