Observational studyJournal of neurology2018
Caregiver burden and its related factors in advanced Parkinson's disease: data from the PREDICT study.
Observational study in Journal of neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 47 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 9 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Factors associated with higher caregiver burden among informal caregivers of Parkinson's disease: A systematic review.Medicine · 2025Pooled it
- Risk factors and intervention of caregiver burden in Parkinson's disease: a systematic review and meta-analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Pooled it
- Caregivers' burden and deep brain stimulation for Parkinson disease: A systematic review of qualitative studies.European journal of neurology · 2024Pooled it
- Continuous Subcutaneous Infusion Delivery of Apomorphine in Parkinson's Disease: A Systematic Review.Movement disorders clinical practice · 2023Pooled it
- Pooled it
- The subjective experience of family caregivers of people living with Parkinson's disease: a meta-ethnography of qualitative literature.Aging clinical and experimental research · 2022Pooled it
- Effects of Levodopa-Carbidopa Intestinal Gel on Dyskinesia and Non-Motor Symptoms Including Sleep: Results from a Meta-Analysis with 24-Month Follow-Up.Journal of Parkinson's disease · 2022Pooled it
- Intrajejunal Infusion of Levodopa/Carbidopa for Advanced Parkinson's Disease: A Systematic Review.Movement disorders : official journal of the Movement Disorder Society · 2021Pooled it
- Social role functioning in Parkinson's disease: A mixed-methods systematic review.International journal of geriatric psychiatry · 2019Pooled it
- Characteristics and Hospitalization Details of Patients with Advanced Parkinson's Disease Receiving Continuous Subcutaneous Infusion of Foslevodopa/Foscarbidopa: Real-World First-Year Descriptive Study from Japan.Neurology and therapy · 2026Article
- What's in a name? reframing advanced Parkinson's disease as a multidimensional state.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Caregiver burden and its relationship with mood and insomnia severity in caregivers of patients with parkinson's disease.Irish journal of medical science · 2026Article
- Tilting the balance toward motor symptoms: Determinants of caregiver burden in late-stage Parkinson's disease.IBRO neuroscience reports · 2026Article
- Determinants of caregiver burden in advanced Parkinson's disease: a multidimensional and sex-sensitive perspective.Frontiers in aging neuroscience · 2026Article
- Caregiver burden in Parkinson's disease: a nationwide observational survey.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Observational
- Should old acquaintance be forgot: A call for recognition and inclusion of advanced Parkinson's disease patients & care partners in evolving research models.Parkinsonism & related disorders · 2025Article
- Real-world disease burden and planned treatment optimization after MANAGE-PD implementation in Germany: a cross-sectional study.Neurological research and practice · 2025Article
- Predicting cognitive impairment in Parkinson's disease: a machine learning approach based on clinical and neuropsychological data.Frontiers in neurology · 2025Article
- Caregiver Burden in Parkinson Disease: A Scoping Review of the Literature from 2017-2022.Journal of geriatric psychiatry and neurology · 2024Article
- Burden, Anxiety, and Depression Among Caregivers of Parkinson's Disease Patients.Journal of Parkinson's disease · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
17 authors at 10 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionCaring for a person with Parkinson's disease (PD) is associated with an increased risk of psychiatric morbidity and persistent distress. The objective of this study was to describe the burden and the related factors of caregivers of advanced PD (APD) patients either treated with continuous dopaminergic delivery systems or standard therapy.
methodsThis cross-sectional, epidemiologic study conducted in 13 Italian sites enrolled PD patients treated with continuous dopaminergic delivering systems [either levodopa/carbidopa intestinal gel (LCIG) infusion or continuous subcutaneous apomorphine infusion (CSAI)] or continuation of standard of care (SOC) with a caregiver. Patient quality of life (QoL) and caregiver burden were assessed using the Parkinson's Disease Questionnaire (PDQ-8) and Zarit Burden Inventory (ZBI), respectively.
results126 patients (mean age 69.3 ± 8 years) and their caregivers (mean age 57.9 ± 12.9) were enrolled. Most caregivers were spouses. Fifty-three patients were treated with LCIG, 19 with CSAI, and 54 with SOC. Mean ZBI scores were 29.6 ± 14.4 for LCIG, 35.8 ± 20.2 for CSAI, and 31.4 ± 16.0 for SOC. Caregivers of LCIG, CSAI, and SOC patients showed no burden or mild/moderate burden in 74, 53, and 63% of the cases, respectively. Mean PDQ-8 scores were 11.25 ± 5.67, 11.26 ± 5.55, and 14.22 ± 6.51 in LCIG, CSAI, and SOC patients. Neurologists considered patients "very much or much improved" in 89, 58, and 13% of the LCIG, CSAI, and SOC groups using the Clinical Global Impression-Global Improvement Scale. Predictors significantly associated with caregiver burden were patients and caregivers' judgment of QoL and caregivers' need to change work.
conclusionsCaregiver burden showed a tendency to be lower when patients are treated with LCIG than with CSAI or SOC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.