ArticleeNeuro
Inhibition of a Descending Prefrontal Circuit Prevents Ketamine-Induced Stress Resilience in Females.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 53 citations in OpenAlex.
- Preliminary evidence that ketamine alters anterior cingulate resting-state functional connectivity in depressed individuals.Translational psychiatry · 2023Trial
- High ovarian hormones present during fear extinction reduce fear relapse through a nigrostriatal dopamine pathway.Biology of sex differences · 2025Article
- Enduring modulation of dorsal raphe nuclei regulates (R,S)-ketamine-mediated resilient stress-coping behavior.Molecular psychiatry · 2025Article
- Distinguishing neural ensembles in the infralimbic cortex that regulate stress vulnerability and coping behavior.Neurobiology of stress · 2025Article
- Ketamine ameliorates activity-based anorexia of adolescent female mice through changes in GluN2B-containing NMDA receptors at postsynaptic cytoplasmic locations of pyramidal neurons and interneurons of medial prefrontal cortex.Brain structure & function · 2024Article
- From helplessness to controllability: toward a neuroscience of resilience.Frontiers in psychiatry · 2023Review
- Prophylactic (R,S)-Ketamine Is Effective Against Stress-Induced Behaviors in Adolescent but Not Aged Mice.The international journal of neuropsychopharmacology · 2022Article
- A Computational Model of Hopelessness and Active-Escape Bias in Suicidality.Computational psychiatry (Cambridge, Mass.) · 2022Article
- Ketamine as a prophylactic resilience-enhancing agent.Frontiers in psychiatry · 2022Review
- Acute (Frontiers in neuroscience · 2022Article
- Fluoroethylnormemantine, a Novel NMDA Receptor Antagonist, for the Prevention and Treatment of Stress-Induced Maladaptive Behavior.Biological psychiatry · 2021Article
- Fluoroethylnormemantine, A Novel Derivative of Memantine, Facilitates Extinction Learning Without Sensorimotor Deficits.The international journal of neuropsychopharmacology · 2021Article
- Impact of impaired glucose metabolism on responses to a psychophysical stressor: modulation by ketamine.Psychopharmacology · 2021Article
- Functional Contribution of the Medial Prefrontal Circuitry in Major Depressive Disorder and Stress-Induced Depressive-Like Behaviors.Frontiers in behavioral neuroscience · 2021Review
- Ketamine metabolite (2R,6R)-hydroxynorketamine reverses behavioral despair produced by adolescent trauma.Pharmacology, biochemistry, and behavior · 2020Article
- Sex-specific neurobiological actions of prophylactic (R,S)-ketamine, (2R,6R)-hydroxynorketamine, and (2S,6S)-hydroxynorketamine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Sex differences in resilience: Experiential factors and their mechanisms.The European journal of neuroscience · 2020Review
- Monoacylglycerol lipase alpha inhibition alters prefrontal cortex excitability and blunts the consequences of traumatic stress in rat.Neuropharmacology · 2020Article
- Sex Differences in the Sustained Effects of Ketamine on Resilience to Chronic Stress.Frontiers in behavioral neuroscience · 2020Article
- Controllable stress elicits circuit-specific patterns of prefrontal plasticity in males, but not females.Brain structure & function · 2019Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Stress is a potent etiological factor in the onset of major depressive disorder and posttraumatic stress disorder (PTSD). Therefore, significant efforts have been made to identify factors that produce resilience to the outcomes of a later stressor, in hopes of preventing untoward clinical outcomes. The NMDA receptor antagonist ketamine has recently emerged as a prophylactic capable of preventing neurochemical and behavioral outcomes of a future stressor. Despite promising results of preclinical studies performed in male rats, the effects of proactive ketamine in female rats remains unknown. This is alarming given that stress-related disorders affect females at nearly twice the rate of males. Here we explore the prophylactic effects of ketamine on stress-induced anxiety-like behavior and the neural circuit-level processes that mediate these effects in female rats. Ketamine given one week prior to an uncontrollable stressor (inescapable tailshock; IS) reduced typical stress-induced activation of the serotonergic (5-HT) dorsal raphe nucleus (DRN) and eliminated DRN-dependent juvenile social exploration (JSE) deficits 24 h after the stressor. Proactive ketamine altered prelimbic cortex (PL) neural ensembles so that a later experience with IS now activated these cells, which it ordinarily would not. Ketamine acutely activated a PL to DRN (PL-DRN) circuit and inhibition of this circuit with Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) at the time of IS one week later prevented stress prophylaxis, suggesting that persistent changes in PL-DRN circuit activity are responsible, at least in part, for mediating long-term effects associated with ketamine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.