Evidence map›Paper›PMID 29515972›Full record

ArticleFrontiers in oncology2018

Genetic Alterations in Essential Thrombocythemia Progression to Acute Myeloid Leukemia: A Case Series and Review of the Literature.

Jackline P Ayres-Silva, Martin H Bonamino, Maria E Gouveia, Barbara C R Monte-Mor, Diego F Coutinho, Adelmo H Daumas, Cristiana Solza, Esteban Braggio, Ilana Renault Zalcberg

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Unraveling the role ofHemaSphere · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. ASXL1/2 mutations and myeloid malignancies.Journal of hematology & oncology · 2022
    Review
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Jackline P Ayres-SilvaBone Marrow Transplantation Unit, Specialized Laboratories, Laboratory of Molecular Biology, National Cancer Institute (INCa), Rio de Janeiro, Brazil.
Martin H BonaminoPrograma de Carcinogênese Molecular, National Cancer Institute (INCa), Rio de Janeiro, Brazil.
Maria E GouveiaHematology Department, Chemotherapy Unit, Hospital Universitario Antonio Pedro - HUAP, Rio de Janeiro, Brazil.
Barbara C R Monte-MorBone Marrow Transplantation Unit, Specialized Laboratories, Laboratory of Molecular Biology, National Cancer Institute (INCa), Rio de Janeiro, Brazil.
Diego F CoutinhoBone Marrow Transplantation Unit, Specialized Laboratories, Laboratory of Molecular Biology, National Cancer Institute (INCa), Rio de Janeiro, Brazil.
Adelmo H DaumasHematology Department, Chemotherapy Unit, Hospital Universitario Antonio Pedro - HUAP, Rio de Janeiro, Brazil.
Cristiana SolzaHematology Unit, Hospital Universitario Pedro Ernesto - HUPE, Rio de Janeiro, Brazil.
Esteban BraggioDepartment of Hematology and Oncology, Mayo Clinic, Scottsdale, AZ, United States.
Ilana Renault ZalcbergBone Marrow Transplantation Unit, Specialized Laboratories, Laboratory of Molecular Biology, National Cancer Institute (INCa), Rio de Janeiro, Brazil.
Hospital Universitário Antônio Pedro · BRHospital Universitário Pedro Ernesto · BRInstituto Nacional do Câncer · BRMayo Clinic in Arizona · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The genetic events associated with transformation of myeloproliferative neoplasms (MPNs) to secondary acute myeloid leukemia (sAML), particularly in the subgroup of essential thrombocythemia (ET) patients, remain incompletely understood. Deep studies using high-throughput methods might lead to a better understanding of genetic landscape of ET patients who transformed to sAML. We performed array-based comparative genomic hybridization (aCGH) and whole exome sequencing (WES) to analyze paired samples from ET and sAML phases. We investigated five patients with previous history of MPN, which four had initial diagnosis of ET (one case harboring

Indexed as

+2parray-based comparative genomic hybridizationessential thrombocythemiamyeloproliferative neoplasmssecondary acute myeloid leukemiawhole exome sequencing

Identifiers

PMID29515972
PMCPMC5826070
OpenAlexW2789360200

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.