ArticleNeuroImage. Clinical2018
Striatal abnormalities in trichotillomania: a multi-site MRI analysis.
Article in NeuroImage. Clinical, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Drug Treatment of Trichotillomania (Hair-Pulling Disorder), Excoriation (Skin-picking) Disorder, and Nail-biting (Onychophagia).Current neuropharmacology · 2019Pooled it
- Morphometric brain MRI findings in hair-pulling and skin-picking disorders in youth.Psychiatry research. Neuroimaging · 2025Article
- Exploring the Relationship Between Psychiatric Illness and Dermatological Disorders: A Narrative Review.Cureus · 2025Review
- Impulsivity in adolescent girls diagnosed with trichotillomania: an evaluation of clinical and neuropsychological characteristics.European child & adolescent psychiatry · 2024Article
- Structural brain network connectivity in trichotillomania (hair-pulling disorder).Brain imaging and behavior · 2023Article
- Neurobiology of subtypes of trichotillomania and skin picking disorder.CNS spectrums · 2023Article
- Body Focused Repetitive Behavior Disorders: Behavioral Models and Neurobiological Mechanisms.Turk psikiyatri dergisi = Turkish journal of psychiatry · 2023Review
- Application of a Machine Learning Algorithm for Structural Brain Images in Chronic Schizophrenia to Earlier Clinical Stages of Psychosis and Autism Spectrum Disorder: A Multiprotocol Imaging Dataset Study.Schizophrenia bulletin · 2022Article
- Neural basis of associative learning in Trichotillomania and skin-picking disorder.Behavioural brain research · 2022Article
- Reward processing in trichotillomania and skin picking disorder.Brain imaging and behavior · 2022Article
- Trichotillomania and Skin-Picking Disorder: An Update.Focus (American Psychiatric Publishing) · 2021Article
- Identifying subtypes of trichotillomania (hair pulling disorder) and excoriation (skin picking) disorder using mixture modeling in a multicenter sample.Journal of psychiatric research · 2021Article
- Duration of illness and cortical thickness in trichotillomania: Preliminary evidence for illness change over time.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2020Article
- Basal ganglia volume and shape in anorexia nervosa.Appetite · 2020Article
- Abnormalities of striatal morphology in gambling disorder and at-risk gambling.CNS spectrums · 2019Article
- Subcortical Shape Abnormalities in Bulimia Nervosa.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Article
- Disentangling Reward Processing in Trichotillomania: 'Wanting' and 'Liking' Hair Pulling Have Distinct Clinical Correlates.Journal of psychopathology and behavioral assessment · 2019Article
- Current Psychopharmacology of Obsessive-Compulsive Spectrum Disorders.Current neuropharmacology · 2019Article
- Trichotillomania (hair pulling disorder).Indian journal of psychiatry · 2019Review
- Trichotillomania is more related to Tourette disorder than to obsessive-compulsive disorder.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Trichotillomania (hair-pulling disorder) is characterized by the repetitive pulling out of one's own hair, and is classified as an Obsessive-Compulsive Related Disorder. Abnormalities of the ventral and dorsal striatum have been implicated in disease models of trichotillomania, based on translational research, but direct evidence is lacking. The aim of this study was to elucidate subcortical morphometric abnormalities, including localized curvature changes, in trichotillomania. De-identified MRI scans were pooled by contacting authors of previous peer-reviewed studies that examined brain structure in adult patients with trichotillomania, following an extensive literature search. Group differences on subcortical volumes of interest were explored (t-tests) and localized differences in subcortical structure morphology were quantified using permutation testing. The pooled sample comprised N=68 individuals with trichotillomania and N=41 healthy controls. Groups were well-matched in terms of age, gender, and educational levels. Significant volumetric reductions were found in trichotillomania patients versus controls in right amygdala and left putamen. Localized shape deformities were found in bilateral nucleus accumbens, bilateral amygdala, right caudate and right putamen. Structural abnormalities of subcortical regions involved in affect regulation, inhibitory control, and habit generation, play a key role in the pathophysiology of trichotillomania. Trichotillomania may constitute a useful model through which to better understand other compulsive symptoms. These findings may account for why certain medications appear effective for trichotillomania, namely those modulating subcortical dopamine and glutamatergic function. Future work should study the state versus trait nature of these changes, and the impact of treatment.
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