Evidence map›Paper›PMID 29515912›Full record

ArticleConvergent science physical oncology2017

Review article: Novel technologies in the treatment and monitoring of advanced and relapsed epithelial ovarian cancer.

Paula Cunnea, Sally Gowers, James E Moore, Emmanuel Drakakis, Martyn Boutelle, Christina Fotopoulou

Abstract read
In one paragraph

Article in Convergent science physical oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Paula CunneaDepartment of Surgery and Cancer, Imperial College London.
Sally GowersDepartment of Bioengineering, Imperial College London.
James E MooreDepartment of Bioengineering, Imperial College London.
Emmanuel DrakakisDepartment of Bioengineering, Imperial College London.
Martyn BoutelleDepartment of Bioengineering, Imperial College London.
Christina FotopoulouDepartment of Surgery and Cancer, Imperial College London.

Funding

Transport Phenomena in the Lymphatic SystemU01HL123420 · NHLBI · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI MOORE, JAMES E, ZAWIEJA, DAVID CARL · 2014 to 2018
$2.9M
Lymphatic Fluid Flow Modeling with Active Network ComponentsR01HL094269 · NHLBI · TEXAS ENGINEERING EXPERIMENT STATION · PI KAUNAS, ROLAND RAYMOND · 2009 to 2012
$2.7M
Stented Artery Wall Stresses and RetenosisR01EB000115 · NIBIB · TEXAS ENGINEERING EXPERIMENT STATION · PI MOORE, JAMES E · 2003 to 2006
$1.5M
2007 ASME Summer Bioengineering ConferenceR13HL088915 · NHLBI · TEXAS ENGINEERING EXPERIMENT STATION · PI MOORE, JAMES E · 2007 to 2007
$16k
Medical Research Council MC_PC_14100NHLBI NIH HHS R01 HL094269NHLBI NIH HHS R13 HL088915NHLBI NIH HHS U01 HL123420NIBIB NIH HHS R01 EB000115
6 · The paper itself

Abstract

Epithelial Ovarian cancer (EOC) is the fifth most common cause of cancer death in females in the UK. It has long been recognized to be a set of heterogeneous diseases, with high grade serous being the most common subtype. The majority of patients with EOC present at an advanced stage (FIGO III-IV), and have the largest risk for disease recurrence from which a high percentage will develop resistance to chemotherapy. Despite continual advances in diagnostics, imaging, surgery and treatment of EOC, there has been little variation in the survival rates for patients with EOC. In this review we will introduce novel bioengineering advances in modelling the lymphatic system and real-time tissue monitoring to improve the clinical and therapeutic outcome for patients with EOC. We discuss the advent of the non-invasive "liquid biopsy" in the surveillance of patients undergoing treatment and follow-up. Finally, we present new bioengineering advances for palliative care of patients to lessen symptoms of patients with ascites and improve quality of life.

Identifiers

PMID29515912
PMCPMC5837061

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.