Evidence map›Paper›PMID 29515860›Full record

ArticleRoyal Society open science2018

Bifunctional fluorescent probes for detection of amyloid aggregates and reactive oxygen species.

Lisa-Maria Needham, Judith Weber, James W B Fyfe, Omaru M Kabia, Dung T Do, Ewa Klimont, Yu Zhang, Margarida Rodrigues, Christopher M Dobson, Sonia Ghandi and 3 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Royal Society open science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Crosstalk between Oxidative Stress and Tauopathy.International journal of molecular sciences · 2019
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Lisa-Maria NeedhamDepartment of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Judith WeberDepartment of Physics, University of Cambridge, JJ Thomson Avenue, Cambridge, CB3 0HE, UK.
James W B FyfeDepartment of Chemistry, Indiana University, 800 E. Kirkwood Avenue, Bloomington, IN 47405, USA.
Omaru M KabiaDepartment of Chemistry, Indiana University, 800 E. Kirkwood Avenue, Bloomington, IN 47405, USA.
Dung T DoDepartment of Chemistry, Indiana University, 800 E. Kirkwood Avenue, Bloomington, IN 47405, USA.
Ewa KlimontDepartment of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Yu ZhangDepartment of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Margarida RodriguesDepartment of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Christopher M DobsonDepartment of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Sonia GhandiDepartment of Molecular Neuroscience, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK.
Sarah E BohndiekDepartment of Physics, University of Cambridge, JJ Thomson Avenue, Cambridge, CB3 0HE, UK.
Thomas N SnaddonDepartment of Chemistry, Indiana University, 800 E. Kirkwood Avenue, Bloomington, IN 47405, USA.
Steven F LeeDepartment of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.ORCID 0000-0003-4492-5139

Funding

Cancer Research UK 16465Cancer Research UK 21142
6 · The paper itself

Abstract

Protein aggregation into amyloid deposits and oxidative stress are key features of many neurodegenerative disorders including Parkinson's and Alzheimer's disease. We report here the creation of four highly sensitive bifunctional fluorescent probes, capable of H

Indexed as

fluorophoresprotein aggregationROSsensorssingle-molecule imagingThioflavin T

Identifiers

PMID29515860
PMCPMC5830749

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.