Evidence map›Paper›PMID 29515755›Full record

ArticleOncotarget2018

CGEF-1 regulates mTORC1 signaling during adult longevity and stress response in

Yujie Li, Sandra Finkbeiner, Athina Ganner, Julia Gerber, Marinella Klein, Manuel Grafe, Jakob Kandzia, Antje Thien, Kathrin Thedieck, Gerhard Breves and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. TOR Signaling inGenetics · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yujie LiDepartment of Nephrology, Medical Center, University of Freiburg, Freiburg, Germany.
Sandra FinkbeinerDepartment of Nephrology, Medical Center, University of Freiburg, Freiburg, Germany.
Athina GannerDepartment of Nephrology, Medical Center, University of Freiburg, Freiburg, Germany.
Julia GerberDepartment of Nephrology, Medical Center, University of Freiburg, Freiburg, Germany.
Marinella KleinDepartment of Nephrology, Medical Center, University of Freiburg, Freiburg, Germany.
Manuel GrafeDepartment of Nephrology, Medical Center, University of Freiburg, Freiburg, Germany.
Jakob KandziaDepartment of Nephrology, Medical Center, University of Freiburg, Freiburg, Germany.
Antje ThienDepartment of Nephrology, Medical Center, University of Freiburg, Freiburg, Germany.
Kathrin ThedieckBioinformatics and Molecular Genetics, Faculty of Biology, Albert-Ludwigs-University Freiburg, Freiburg, Germany.
Gerhard BrevesDepartment of Physiology, University of Veterinary Medicine Hannover, Hannover, Germany.
Thomas JankInstitute for Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Freiburg, Germany.
Ralf BaumeisterBioinformatics and Molecular Genetics, Faculty of Biology, Albert-Ludwigs-University Freiburg, Freiburg, Germany.
Gerd WalzDepartment of Nephrology, Medical Center, University of Freiburg, Freiburg, Germany.
Elke Neumann-HaefelinDepartment of Nephrology, Medical Center, University of Freiburg, Freiburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mechanistic target of rapamycin (mTOR) kinase is central to metabolism and growth, and has a conserved role in aging. mTOR functions in two complexes, mTORC1 and mTORC2. In diverse eukaryotes, inhibition of mTORC1 signaling increases lifespan. mTORC1 transduces anabolic signals to stimulate protein synthesis and inhibits autophagy. In this study, we demonstrate that CGEF-1, the

Indexed as

agingC. elegansmTORC1 signalingRhebstress response

Identifiers

PMID29515755
PMCPMC5839386

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.