Evidence map›Paper›PMID 29515620›Full record

ArticleDementia and geriatric cognitive disorders extra

Impairment of the Missing Fundamental Phenomenon in Individuals with Alzheimer's Disease: A Neuropsychological and Voxel-Based Morphometric Study.

Makiko Abe, Ken-Ichi Tabei, Masayuki Satoh, Mari Fukuda, Hironobu Daikuhara, Mariko Shiga, Hirotaka Kida, Hidekazu Tomimoto

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Dementia and geriatric cognitive disorders extra. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Makiko AbeaDepartment of Dementia Prevention and Therapeutics, Graduate School of Medicine, Mie University, Mie, Japan.
Ken-Ichi TabeiaDepartment of Dementia Prevention and Therapeutics, Graduate School of Medicine, Mie University, Mie, Japan.
Masayuki SatohaDepartment of Dementia Prevention and Therapeutics, Graduate School of Medicine, Mie University, Mie, Japan.
Mari FukudaaDepartment of Dementia Prevention and Therapeutics, Graduate School of Medicine, Mie University, Mie, Japan.
Hironobu DaikuharacGraduate School of Medicine, Mie University, Mie, Japan.
Mariko ShigadMie Prefectural Dementia-Related Disease Medical Center, Mie, Japan.
Hirotaka KidaaDepartment of Dementia Prevention and Therapeutics, Graduate School of Medicine, Mie University, Mie, Japan.
Hidekazu TomimotoaDepartment of Dementia Prevention and Therapeutics, Graduate School of Medicine, Mie University, Mie, Japan.
Mie University · JPMie Prefectural Education Center · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimsThe missing fundamental phenomenon (MFP) is a universal pitch perception illusion that occurs in animals and humans. In this study, we aimed to determine whether the MFP is impaired in patients with Alzheimer's disease (AD) using an auditory pitch perception experiment. We further examined anatomical correlates of the MFP in patients with AD by measuring gray matter volume (GMV) on magnetic resonance images via voxel-based morphometric analysis.

methodsWe prospectively enrolled 29 patients with AD and 20 healthy older adults. Auditory stimuli included 12 melodies of Japanese nursery songs that were expected to be familiar to participants. We constructed the melodies using pure and missing fundamental tones (MFTs).

resultsPatients with AD exhibited significantly poorer performance on the MFT task than healthy controls. MFT scores were positively correlated with GMV in the bilateral insula and temporal poles, left inferior frontal gyrus, right entorhinal cortex, and right cerebellum.

conclusionsThese results suggest that impairments in the MFP represent a manifestation of the degeneration of auditory-related brain regions in AD. Further studies are required to more fully elucidate the neural mechanisms underlying auditory impairments in patients with AD and related dementia disorders.

Indexed as

Alzheimer's diseaseDementiaMagnetic resonance imagingMissing fundamental phenomenonPitch perceptionVoxel-based morphometry

Identifiers

PMID29515620
PMCPMC5836147
OpenAlexW2793213029

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.