Evidence map›Paper›PMID 29515537›Full record

ArticleFrontiers in microbiology2018

Intra-species Genomic and Physiological Variability Impact Stress Resistance in Strains of Probiotic Potential.

Jason W Arnold, Joshua B Simpson, Jeffrey Roach, Jakub Kwintkiewicz, M Andrea Azcarate-Peril

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Isolation and Characterization of Lactic Acid Bacteria From "International journal of microbiology · 2025
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  5. Review
  6. Article
  7. Article
  8. Effects of SynbioticFoods (Basel, Switzerland) · 2023
    Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Analysis ofFrontiers in nutrition · 2022
    Article
  15. Genomic Insight IntoFrontiers in microbiology · 2022
    Article
  16. Probiogenomics ofMicroorganisms · 2021
    Article
  17. Article
  18. Article
  19. Review
  20. Frontiers in microbiology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jason W ArnoldDivision of Gastroenterology and Hepatology, Department of Medicine, Microbiome Core Facility, Center for Gastrointestinal Biology and Disease, School of Medicine, University of North Carolina, Chapel Hill, NC, United States.
Joshua B SimpsonDepartment of Chemistry, College of Arts and Sciences, University of North Carolina, Chapel Hill, NC, United States.
Jeffrey RoachResearch Computing, University of North Carolina, Chapel Hill, NC, United States.
Jakub KwintkiewiczDivision of Gastroenterology and Hepatology, Department of Medicine, Microbiome Core Facility, Center for Gastrointestinal Biology and Disease, School of Medicine, University of North Carolina, Chapel Hill, NC, United States.
M Andrea Azcarate-PerilDivision of Gastroenterology and Hepatology, Department of Medicine, Microbiome Core Facility, Center for Gastrointestinal Biology and Disease, School of Medicine, University of North Carolina, Chapel Hill, NC, United States.
University of North Carolina at Chapel Hill · US

Funding

PILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Temitope O. Keku · 1985 to 2026
$30.5M
NIDDK NIH HHS P30 DK034987
6 · The paper itself

Abstract

Large-scale microbiome studies have established that most of the diversity contained in the gastrointestinal tract is represented at the strain level; however, exhaustive genomic and physiological characterization of human isolates is still lacking. With increased use of probiotics as interventions for gastrointestinal disorders, genomic and functional characterization of novel microorganisms becomes essential. In this study, we explored the impact of strain-level genomic variability on bacterial physiology of two novel human

Indexed as

bacterial stressbile salt hydrolase (BSH)intra-Species variabilityLactobacillus rhamnosusprobiotics

Identifiers

PMID29515537
PMCPMC5826259
OpenAlexW2791949373

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.