ArticleFrontiers in physiology2018
Article in Frontiers in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 103 citations in OpenAlex.
- Cephalopod Behavior: From Neural Plasticity to Consciousness.Frontiers in systems neuroscience · 2021Pooled it
- Molecular Characterization and Signaling Mechanisms of a Corazonin-Type System in Octopus minor.Marine biotechnology (New York, N.Y.) · 2026Article
- Using magnetic nanoparticles to explore symbiotic interactions.Scientific reports · 2026Article
- Assessing Local Anesthesia in Octopus bimaculoides to Provide Analgesia.Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Article
- Molecular cloning, characterization, and expression analysis of two GABAMolecular biology reports · 2026Article
- Euthanasia Methods in Invertebrates: A Critical Narrative Review of Methodological and Welfare Standards.Animals : an open access journal from MDPI · 2026Review
- Neurometabolic rewiring in squid (Sepioteuthis lessoniana) optic lobes drives behavioral plasticity and visual integration under environmental acidification.Communications biology · 2026Article
- Octopus 'hypnosis': inducing tonic immobility for studying local sensorimotor responses and arm-sucker coordination.Biology open · 2025Article
- Neural models and algorithms for sensorimotor control of an octopus arm.Biological cybernetics · 2025Article
- Neural responses to light stimulation in the octopus arm.The Journal of experimental biology · 2025Article
- Animal welfare risks from commercial practices involving cephalopod molluscs and decapod crustaceans.Animal welfare (South Mimms, England) · 2025Review
- Single unit electrophysiology recordings and computational modeling can predict octopus arm movement.bioRxiv : the preprint server for biology · 2024Article
- Morphology, Histology, and Transcriptome Analysis of Gonadal Development in Octopus minor (Sasaki, 1920).Marine biotechnology (New York, N.Y.) · 2023Article
- The Use of Isoflurane and Adjunctive Magnesium Chloride Provides Fast, Effective Anaesthetization ofAnimals : an open access journal from MDPI · 2023Article
- Characterization of Current Husbandry and Veterinary Care Practices of the Giant Pacific Octopus (Veterinary sciences · 2023Article
- Mechanosensory signal transmission in the arms and the nerve ring, an interarm connective, ofiScience · 2023Article
- Evaluation of Candidates for Systemic Analgesia and General Anesthesia in the Emerging Model Cephalopod,Biology · 2023Article
- Article
- Diffusion MRI Connections in the Octopus Brain.Experimental neurobiology · 2022Article
- The effect of unexpected rewards on decision making in cuttlefish.Scientific reports · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cephalopod molluscs are among the most behaviorally and neurologically complex invertebrates. As they are now included in research animal welfare regulations in many countries, humane and effective anesthesia is required during invasive procedures. However, currently there is no evidence that agents believed to act as anesthetics produce effects beyond immobility. In this study we demonstrate, for the first time, that two of the most commonly used agents in cephalopod general anesthesia, magnesium chloride and ethanol, are capable of producing strong and reversible blockade of afferent and efferent neural signal; thus they are genuine anesthetics, rather than simply sedating agents that render animals immobile but not insensible. Additionally, we demonstrate that injected magnesium chloride and lidocaine are effective local anesthetic agents. This represents a considerable advance for cephalopod welfare. Using a reversible, minimally invasive recording procedure, we measured activity in the pallial nerve of cuttlefish (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.